Table 3.

Renal hemodynamics in obese rats studied on a NS and HS intake (n)

GFR, ml·100 g−1·min−1ERPF, ml·100 g−1·min−1FF, %
NS obese
    Vehicle (9)0.82±0.033.6±0.223.3±1.7
    Pioglitazone (6)0.43±0.02*2.1±0.120.9±1.4
HS obese
    Vehicle (6)0.92±0.063.8±0.425.7±2.6
    Pioglitazone (5)1.1±0.29.1±3.0*14.2±3.1*
  • Values are means ± SE. GFR, glomerular filtration rate; ERPF, effective renal plasma flow; FF, filtration fraction.

  • * P < 0.05 vs. vehicle;

  • P < 0.05;

  • P < 0.005 vs. HS.