Table 2.

Changes in endothelial and hormonal variables before and after l-arginine and placebo therapy

l-ArgininePlaceboP Value
BeforeAfterBeforeAfterTime effectInteraction effect
Incremental area NOx, μmol/l·6 min9.2±5.032.8±5.79.5±2.68.9±2.7<0.005<0.002
Fasting cGMP, μmol/ml2.30±0.23.56±0.32.25±0.12.70±0.2<0.005<0.001
Incremental area cGMP, μmol/ml·6 min1.50±0.35.45±0.61.61±0.23.67±0.2<0.0001<0.001
Fasting ET-1 pg/ml10.5±0.57.4±0.49.5±0.413.7±1.0<0.37<0.0001
Incremental area ET-1, pg/ml·6 min12.4±2.60.4±1.111.2±2.611.1±2.4<0.01<0.01
Basal ec-SOD, ng/ml84.6±7.0113.9±12.386.8±7.477.3±4.9<0.22<0.03
Incremental area ec-SOD, mol/ml·6 min72.8±31.8210.5±20.637.1±21.995.7±10.4<0.0002<0.05
Adiponectin, ng/ml4.0±0.75.6±0.64.2±0.64.2±0.5<0.02<0.03
Leptin, ng/ml62.4±7.748.0±7.853.0±9.548.6±9.7<0.01<0.07
Leptin-to-adiponectin ratio21.8±3.99.4±1.318.1±5.513.7±3.2<0.001<0.05
  • Values are means ± SE. NOx, nitrate/nitrite; ET-1, endothelin-1; ec-SOD, extracellular; superoxide dismutase.