Table 3.

Body composition analysis

Testosterone DoseBaselineWeek 20Change from BaselineP vs. Zero Change
Fat-free mass (kg) by underwater weighing
(overall ANOVA P = 0.0001)
25 mg61.1 ± 2.758.1 ± 1.7−1.0 ± 0.50.0695
50 mg66.1 ± 2.565.7 ± 2.0+0.6 ± 0.40.1324
125 mg66.0 ± 2.167.9 ± 2.7+3.4 ± 0.80.0024
300 mg66.9 ± 2.472.4 ± 2.8+5.2 ± 0.80.0001
600 mg64.2 ± 2.272.1 ± 2.4+7.9 ± 0.60.0001
Fat mass (kg) by underwater weighing
(overall ANOVA P = 0.0001)
25 mg8.3 ± 1.411.3 ± 1.6+3.1 ± 0.70.0014
50 mg10.9 ± 1.414.3 ± 1.7+3.5 ± 1.00.0096
125 mg12.2 ± 2.010.9 ± 2.1+0.01 ± 0.50.9820
300 mg11.4 ± 1.610.9 ± 1.7−0.5 ± 0.60.4134
600 mg9.4 ± 1.98.8 ± 1.9−1.1 ± 0.70.1132
Fat-free mass (kg) by DEXA scan (overall ANOVA P = 0.0001)
25 mg53.6 ± 1.853.4 ± 2.0+0.4 ± 0.30.2198
50 mg58.6 ± 2.359.2 ± 2.5+1.1 ± 0.90.2313
125 mg60.1 ± 2.163.1 ± 2.3+2.9 ± 0.80.0054
300 mg59.0 ± 2.764.3 ± 2.2+5.5 ± 0.70.0001
600 mg57.4 ± 1.966.3 ± 2.4+8.9 ± 0.80.0001
Fat mass (kg) by DEXA scan (overall ANOVA P = 0.0004)
25 mg10.0 ± 1.813.7 ± 1.4+3.6 ± 1.50.0326
50 mg15.4 ± 1.217.9 ± 1.2+2.6 ± 1.00.0324
125 mg15.2 ± 2.015.2 ± 1.9−0.3 ± 0.80.6882
300 mg16.3 ± 1.215.41 ± 1.5−0.9 ± 0.60.1834
600 mg14.2 ± 1.912.0 ± 1.5−2.0 ± 0.70.0141
Ratio of total body water to fat-free mass (percent)
(overall ANOVA for change from baseline, P = 0.270)
25 mg62.7 ± 2.763.7 ± 2.1+1.1 ± 2.4
50 mg62.0 ± 1.963.8 ± 2.4+2.0 ± 2.0
125 mg67.0 ± 1.763.5 ± 3.0−3.8 ± 1.6
300 mg61.6 ± 2.764.6 ± 3.1+2.1 ± 2.5
600 mg65.3 ± 2.467.4 ± 2.8+2.5 ± 1.7
  • Values on each day represent the mean (±SE) of all available values on that day. However, the change represents the difference between paired values only. Ratios of total body water assessed by deuterium water dilution to fat-free mass measured by underwater weighing were calculated for each subject and averaged across subjects within each group. DEXA, dual-energy X-ray absorptiometry.