Table 2.

Serum total and free testosterone, LH, FSH, SHBG, and IGF-I levels

Testosterone
Dose
BaselineWeek 16Change from BaselineP vs. Zero Change
Testosterone (ng/dl) (overall ANOVA P = 0.0001)
25 mg593 ± 48253 ± 66−340 ± 850.0029
50 mg566 ± 78306 ± 58−260 ± 640.0037
125 mg553 ± 53570 ± 7557 ± 750.7425
300 mg653 ± 501,345 ± 139691 ± 1430.0005
600 mg632 ± 632,370 ± 1501,737 ± 1560.0001
Free testosterone (pg/ml) (overall ANOVA P = 0.0001)
25 mg62 ± 629 ± 5−33 ± 80.0014
50 mg57 ± 632 ± 3−25 ± 50.0009
125 mg49 ± 552 ± 83 ± 70.8601
300 mg71 ± 7138 ± 2167 ± 180.0012
600 mg64 ± 5275 ± 30211 ± 310.0001
LH (U/l) (overall ANOVA P = 0.8054)
25 mg3.5 ± 0.40.3 ± 0.1−3.2 ± 0.40.0001
50 mg3.8 ± 0.30.6 ± 0.3−3.0 ± 0.40.0008
125 mg3.4 ± 0.30.5 ± 0.1−2.8 ± 0.40.0001
300 mg3.7 ± 0.50.6 ± 0.1−3.5 ± 0.50.0002
600 mg3.3 ± 0.30.6 ± 0.4−2.9 ± 0.40.0001
SHBG (nmol/l) (overall ANOVA P = 0.0001)
25 mg29.1 ± 2.928.5 ± 3.6−0.6 ± 2.90.8497
50 mg24.4 ± 3.421.1 ± 3.2−3.3 ± 1.10.0202
125 mg33.1 ± 4.228.9 ± 3.8−4.2 ± 2.60.1410
300 mg31.4 ± 3.822.4 ± 3.9−9.1 ± 3.70.0348
600 mg40.1 ± 4.920.6 ± 3.2−19.5 ± 2.80.0001
IGF-I (ng/ml) (overall ANOVA P = 0.0001)
25 mg268 ± 26261 ± 35−7 ± 190.7462
50 mg246 ± 14225 ± 12−20 ± 100.0797
125 mg299 ± 24282 ± 31−18 ± 170.3284
300 mg314 ± 24388 ± 3074 ± 280.0272
600 mg227 ± 20304 ± 2177 ± 130.0001
  • Values on each day represent the mean (±SE) of all available values on that day. However, the change represents the difference between paired values only. Treatment values represent the day 113 (week 16) values, obtained 1 wk after the previous testosterone injection. We used week 16 rather thanweek 20 values because week 20 values were not always drawn exactly 1 wk after the previous injection. LH and FSH, luteinizing and follicle-stimulating hormones, respectively; SHBG, sex hormone-binding globulin; IGF-I, insulin-like growth factor I. To convert total testosterone levels to nmol/l, multiply by 0.03467. To convert free testosterone levels to pg/ml, multiply by 3.467.