AJP - Endocrinology and Metabolism -- Table of Contents (December 1 2008, 295 [6])

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EDITORIAL FOCUS:

Philippe A. Halban: The right stuff: β-cell channels, cycles, and sensors
Am J Physiol Endocrinol Metab 295: E1277-E1278, 2008. First published August 19, 2008; doi:10.1152/ajpendo.90692.2008 [Full Text] [PDF]

REVIEWS:

Benoit R. Gauthier and Claes B. Wollheim: Synaptotagmins bind calcium to release insulin
Am J Physiol Endocrinol Metab 295: E1279-E1286, 2008. First published August 19, 2008; doi:10.1152/ajpendo.90568.2008 [Abstract] [Full Text] [PDF]

Mette V. Jensen, Jamie W. Joseph, Sarah M. Ronnebaum, Shawn C. Burgess, A. Dean Sherry, and Christopher B. Newgard: Metabolic cycling in control of glucose-stimulated insulin secretion
Am J Physiol Endocrinol Metab 295: E1287-E1297, 2008. First published August 26, 2008; doi:10.1152/ajpendo.90604.2008 [Abstract] [Full Text] [PDF]

Marcia Hiriart and Lydia Aguilar-Bryan: Channel regulation of glucose sensing in the pancreatic β-cell
Am J Physiol Endocrinol Metab 295: E1298-E1306, 2008. First published October 21, 2008; doi:10.1152/ajpendo.90493.2008 [Abstract] [Full Text] [PDF]

ARTICLES:

Jonathan M. Peterson, Yan Wang, Randall W. Bryner, David L. Williamson, and Stephen E. Alway: Bax signaling regulates palmitate-mediated apoptosis in C₂C₁₂ myotubes
Am J Physiol Endocrinol Metab 295: E1307-E1314, 2008. First published October 7, 2008; doi:10.1152/ajpendo.00738.2007 [Abstract] [Full Text] [PDF]

Yvette C. Luiking, Marcella M. Hallemeesch, Marcel C. van de Poll, Cornelis H. C. Dejong, Wouter J. de Jonge, Wouter H. Lamers, and Nicolaas E. P. Deutz: Reduced citrulline availability by OTC deficiency in mice is related to reduced nitric oxide production
Am J Physiol Endocrinol Metab 295: E1315-E1322, 2008. First published August 12, 2008; doi:10.1152/ajpendo.00055.2008 [Abstract] [Full Text] [PDF]

Sofianos Andrikopoulos, Amy R. Blair, Nadia Deluca, Barbara C. Fam, and Joseph Proietto: Evaluating the glucose tolerance test in mice
Am J Physiol Endocrinol Metab 295: E1323-E1332, 2008. First published September 23, 2008; doi:10.1152/ajpendo.90617.2008 [Abstract] [Full Text] [PDF]

Micah J. Drummond, John J. McCarthy, Christopher S. Fry, Karyn A. Esser, and Blake B. Rasmussen: Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids
Am J Physiol Endocrinol Metab 295: E1333-E1340, 2008. First published September 30, 2008; doi:10.1152/ajpendo.90562.2008 [Abstract] [Full Text] [PDF]

E. M. E. van Straten, N. C. A. Huijkman, J. F. W. Baller, F. Kuipers, and T. Plösch: Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism
Am J Physiol Endocrinol Metab 295: E1341-E1348, 2008. First published October 7, 2008; doi:10.1152/ajpendo.90597.2008 [Abstract] [Full Text] [PDF] [Supplemental Tables]

Dong-Ye Youn, Dong-Hyoung Lee, Mi-Hyun Lim, Jung-Sook Yoon, Ji Hee Lim, Seung Eun Jung, Chung Eun Yeum, Cheol Whee Park, Ho-Joong Youn, Jae-Seon Lee, Seong-Beom Lee, Masahito Ikawa, Masaru Okabe, Yoshihide Tsujimoto, and Jeong-Hwa Lee: Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus
Am J Physiol Endocrinol Metab 295: E1349-E1357, 2008. First published October 7, 2008; doi:10.1152/ajpendo.90704.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Cynthia F. Zizola, Gary J. Schwartz, and Silke Vogel: Cellular retinol-binding protein type III is a PPAR ${gamma}$ target gene and plays a role in lipid metabolism
Am J Physiol Endocrinol Metab 295: E1358-E1368, 2008. First published October 7, 2008; doi:10.1152/ajpendo.90464.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Yongjie Ma, Leyuan Xu, Daniel Rodriguez-Agudo, Xiaobo Li, Douglas M. Heuman, Phillip B. Hylemon, William M. Pandak, and Shunlin Ren: 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway
Am J Physiol Endocrinol Metab 295: E1369-E1379, 2008. First published October 14, 2008; doi:10.1152/ajpendo.90555.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures]

Mark J. Holness, Gemma K. Greenwood, Nicholas D. Smith, and Mary C. Sugden: PPAR ${alpha}$ activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism
Am J Physiol Endocrinol Metab 295: E1380-E1389, 2008. First published October 14, 2008; doi:10.1152/ajpendo.90700.2008 [Abstract] [Full Text] [PDF]

Jian-Qiu Gu, Shoichiro Ikuyama, Ping Wei, Bin Fan, Jun-ichi Oyama, Toyoshi Inoguchi, and Junji Nishimura: Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages
Am J Physiol Endocrinol Metab 295: E1390-E1400, 2008. First published October 14, 2008; doi:10.1152/ajpendo.90543.2008 [Abstract] [Full Text] [PDF]

Gilberto Paz-Filho, Karin Esposito, Barry Hurwitz, Anil Sharma, Chuanhui Dong, Victor Andreev, Tuncay Delibasi, Halil Erol, Alejandro Ayala, Ma-Li Wong, and Julio Licinio: Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
Am J Physiol Endocrinol Metab 295: E1401-E1408, 2008. First published October 14, 2008; doi:10.1152/ajpendo.90450.2008 [Abstract] [Full Text] [PDF]

Helen L. Eley, Steven T. Russell, and Michael J. Tisdale: Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by β-hydroxy-β-methylbutyrate
Am J Physiol Endocrinol Metab 295: E1409-E1416, 2008. First published October 14, 2008; doi:10.1152/ajpendo.90530.2008 [Abstract] [Full Text] [PDF]

Helen L. Eley, Steven T. Russell, and Michael J. Tisdale: Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor- ${alpha}$ and angiotensin II by β-hydroxy-β-methylbutyrate
Am J Physiol Endocrinol Metab 295: E1417-E1426, 2008. First published October 7, 2008; doi:10.1152/ajpendo.90567.2008 [Abstract] [Full Text] [PDF]

Boubacar Benziane, Timothy J. Burton, Brendan Scanlan, Dana Galuska, Benedict J. Canny, Alexander V. Chibalin, Juleen R. Zierath, and Nigel K. Stepto: Divergent cell signaling after short-term intensified endurance training in human skeletal muscle
Am J Physiol Endocrinol Metab 295: E1427-E1438, 2008. First published September 30, 2008; doi:10.1152/ajpendo.90428.2008 [Abstract] [Full Text] [PDF]

Wenyu Huang, Maricedes Acosta-Martínez, Teresa H. Horton, and Jon E. Levine: Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels
Am J Physiol Endocrinol Metab 295: E1439-E1446, 2008. First published October 7, 2008; doi:10.1152/ajpendo.90615.2008 [Abstract] [Full Text] [PDF]

Natalie Lefort, Emmanuelle St.-Amand, Sébastien Morasse, Claude H. Côté, and André Marette: The ${alpha}$ -subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro
Am J Physiol Endocrinol Metab 295: E1447-E1454, 2008. First published September 23, 2008; doi:10.1152/ajpendo.90362.2008 [Abstract] [Full Text] [PDF]

Feng Wang, Wei Wang, Kristiina Wähälä, Herman Adlercreutz, Elina Ikonen, and Matti J. Tikkanen: Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl esters
Am J Physiol Endocrinol Metab 295: E1455-E1461, 2008. First published September 16, 2008; doi:10.1152/ajpendo.90527.2008 [Abstract] [Full Text] [PDF]

Andrea De Gaetano, Thomas Hardy, Benoit Beck, Eyas Abu-Raddad, Pasquale Palumbo, Juliana Bue-Valleskey, and Niels Pørksen: Mathematical models of diabetes progression
Am J Physiol Endocrinol Metab 295: E1462-E1479, 2008. First published September 9, 2008; doi:10.1152/ajpendo.90444.2008 [Abstract] [Full Text] [PDF]

Tanja Brenner and Kevin M. O'Shaughnessy: Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion
Am J Physiol Endocrinol Metab 295: E1480-E1486, 2008. First published October 14, 2008; doi:10.1152/ajpendo.90652.2008 [Abstract] [Full Text] [PDF]

Ixchel M. Brennan, Tanya J. Little, Kate L. Feltrin, Andre J. P. M. Smout, Judith M. Wishart, Michael Horowitz, and Christine Feinle-Bisset: Dose-dependent effects of cholecystokinin-8 on antropyloroduodenal motility, gastrointestinal hormones, appetite, and energy intake in healthy men
Am J Physiol Endocrinol Metab 295: E1487-E1494, 2008. First published October 28, 2008; doi:10.1152/ajpendo.90791.2008 [Abstract] [Full Text] [PDF]

Angela Szeto, Daniel A. Nation, Armando J. Mendez, Juan Dominguez-Bendala, Larry G. Brooks, Neil Schneiderman, and Philip M. McCabe: Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells
Am J Physiol Endocrinol Metab 295: E1495-E1501, 2008. First published October 21, 2008; doi:10.1152/ajpendo.90718.2008 [Abstract] [Full Text] [PDF]

Biao Lu, Yang Lu, Arthur H. Moser, Judy K. Shigenaga, Carl Grunfeld, and Kenneth R. Feingold: LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes
Am J Physiol Endocrinol Metab 295: E1502-E1509, 2008. First published October 21, 2008; doi:10.1152/ajpendo.90323.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures]

Amale A. Lteif, Angie D. Fulford, Robert V. Considine, Inessa Gelfand, Alain D. Baron, and Kieren J. Mather: Hyperinsulinemia fails to augment ET-1 action in the skeletal muscle vascular bed in vivo in humans
Am J Physiol Endocrinol Metab 295: E1510-E1517, 2008. First published October 28, 2008; doi:10.1152/ajpendo.90549.2008 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Cover: Islets of Langerhans in the pancreas of a 3-mo-old wild-type mouse (C57BL/6J × CBA F₁ genetic background). A 4-μm-thick section of the pancreas fixed in Bouin's fluid and embedded in paraffin was stained with hematoxylin-eosin. The image was obtained with an Axioplan microscope (×20 objective) coupled to an Axiocam HRc digital camera. From Pascal SM, Guiot Y, Pelengaris S, Khan M, Jonas J. Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets. Am J Physiol Endocrinol Metab 295: E92–E102, 2008.