AJP - Endocrinology and Metabolism -- Table of Contents (May 1 2008, 294 [5])

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EDITORIAL FOCUS:

Martin G. Myers, Jr.: Metabolic sensing and regulation by the hypothalamus
Am J Physiol Endocrinol Metab 294: E809-E809, 2008; doi:10.1152/ajpendo.90282.2008 [Full Text] [PDF]

REVIEWS:

Eva Rother, A. Christine Könner, and Jens C. Brüning: Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism
Am J Physiol Endocrinol Metab 294: E810-E816, 2008. First published February 19, 2008; doi:10.1152/ajpendo.00685.2007 [Abstract] [Full Text] [PDF]

Qian Gao and Tamas L. Horvath: Cross-talk between estrogen and leptin signaling in the hypothalamus
Am J Physiol Endocrinol Metab 294: E817-E826, 2008. First published March 11, 2008; doi:10.1152/ajpendo.00733.2007 [Abstract] [Full Text] [PDF]

Jennifer W. Hill, Joel K. Elmquist, and Carol F. Elias: Hypothalamic pathways linking energy balance and reproduction
Am J Physiol Endocrinol Metab 294: E827-E832, 2008. First published February 19, 2008; doi:10.1152/ajpendo.00670.2007 [Abstract] [Full Text] [PDF]

ARTICLES:

Masaki Tsunoda, Naoki Kobayashi, Tomohiro Ide, Mari Utsumi, Michiaki Nagasawa, and Koji Murakami: A novel PPAR ${alpha}$ agonist ameliorates insulin resistance in dogs fed a high-fat diet
Am J Physiol Endocrinol Metab 294: E833-E840, 2008. First published January 22, 2008; doi:10.1152/ajpendo.00627.2007 [Abstract] [Full Text] [PDF]

Jukka Westerbacka, Anja Cornér, Maria Kolak, Janne Makkonen, Ursula Turpeinen, Anders Hamsten, Rachel M. Fisher, and Hannele Yki-Järvinen: Insulin regulation of MCP-1 in human adipose tissue of obese and lean women
Am J Physiol Endocrinol Metab 294: E841-E845, 2008. First published February 12, 2008; doi:10.1152/ajpendo.00653.2006 [Abstract] [Full Text] [PDF]

Antonio Cervera, Estela Wajcberg, Apiradee Sriwijitkamol, Marianella Fernandez, Pengou Zuo, Curtis Triplitt, Nicolas Musi, Ralph A. DeFronzo, and Eugenio Cersosimo: Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes
Am J Physiol Endocrinol Metab 294: E846-E852, 2008. First published March 11, 2008; doi:10.1152/ajpendo.00030.2008 [Abstract] [Full Text] [PDF]

Nicole M. Sanders, Charles W. Wilkinson, Gerald J. Taborsky, Jr., Salwa Al-Noori, Wendi Daumen, Aryana Zavosh, and Dianne P. Figlewicz: The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia
Am J Physiol Endocrinol Metab 294: E853-E860, 2008. First published March 11, 2008; doi:10.1152/ajpendo.00772.2007 [Abstract] [Full Text] [PDF]

Glenn D. Wadley, Andrew L. Siebel, Greg J. Cooney, Glenn K. McConell, Mary E. Wlodek, and Julie A. Owens: Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex-specific manner in the adult rat
Am J Physiol Endocrinol Metab 294: E861-E869, 2008. First published March 4, 2008; doi:10.1152/ajpendo.00037.2008 [Abstract] [Full Text] [PDF]

Katherine A. Robinson and Maria G. Buse: Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation
Am J Physiol Endocrinol Metab 294: E870-E881, 2008. First published February 26, 2008; doi:10.1152/ajpendo.00644.2007 [Abstract] [Full Text] [PDF]

John J. Dubé, Francesca Amati, Maja Stefanovic-Racic, Frederico G. S. Toledo, Sarah E. Sauers, and Bret H. Goodpaster: Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited
Am J Physiol Endocrinol Metab 294: E882-E888, 2008. First published March 4, 2008; doi:10.1152/ajpendo.00769.2007 [Abstract] [Full Text] [PDF]

Yasuki Higaki, Toshio Mikami, Nobuharu Fujii, Michael F. Hirshman, Katsuhiro Koyama, Tetsuya Seino, Keitaro Tanaka, and Laurie J. Goodyear: Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway
Am J Physiol Endocrinol Metab 294: E889-E897, 2008. First published February 26, 2008; doi:10.1152/ajpendo.00150.2007 [Abstract] [Full Text] [PDF]

Kazuto Takahashi, Shinya Yamaguchi, Tatsuhiro Shimoyama, Hiroyuki Seki, Kaoru Miyokawa, Hidenori Katsuta, Toshiaki Tanaka, Katsuhiko Yoshimoto, Hideki Ohno, Shinya Nagamatsu, and Hitoshi Ishida: JNK- and I ${kappa}$ B-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro
Am J Physiol Endocrinol Metab 294: E898-E909, 2008. First published February 26, 2008; doi:10.1152/ajpendo.00131.2007 [Abstract] [Full Text] [PDF]

Dawn K. Coletta, Bogdan Balas, Alberto O. Chavez, Muhammad Baig, Muhammad Abdul-Ghani, Sangeeta R. Kashyap, Franco Folli, Devjit Tripathy, Lawrence J. Mandarino, John E. Cornell, Ralph A. DeFronzo, and Christopher P. Jenkinson: Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo
Am J Physiol Endocrinol Metab 294: E910-E917, 2008. First published March 11, 2008; doi:10.1152/ajpendo.00607.2007 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]

David L. Allen, Allison S. Cleary, Kristin J. Speaker, Sarah F. Lindsay, Jill Uyenishi, Jason M. Reed, Molly C. Madden, and Ryan S. Mehan: Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice
Am J Physiol Endocrinol Metab 294: E918-E927, 2008. First published March 11, 2008; doi:10.1152/ajpendo.00798.2007 [Abstract] [Full Text] [PDF]

Katie Robertson, Yarong Lu, Kristine De Jesus, Bing Li, Qing Su, P. Kay Lund, and Jun-Li Liu: A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia, and significant resistance to experimental diabetes
Am J Physiol Endocrinol Metab 294: E928-E938, 2008. First published February 12, 2008; doi:10.1152/ajpendo.00606.2007 [Abstract] [Full Text] [PDF]

Karima Begriche, Philippe Lettéron, Adjé Abbey-Toby, Nathalie Vadrot, Marie-Anne Robin, André Bado, Dominique Pessayre, and Bernard Fromenty: Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice
Am J Physiol Endocrinol Metab 294: E939-E951, 2008. First published March 18, 2008; doi:10.1152/ajpendo.00379.2007 [Abstract] [Full Text] [PDF]

Eva Tudurí, Eliane Filiputti, Everardo M. Carneiro, and Ivan Quesada: Inhibition of Ca²⁺ signaling and glucagon secretion in mouse pancreatic ${alpha}$ -cells by extracellular ATP and purinergic receptors
Am J Physiol Endocrinol Metab 294: E952-E960, 2008. First published March 18, 2008; doi:10.1152/ajpendo.00641.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]

Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, and Ryuichi Ajisaka: Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle
Am J Physiol Endocrinol Metab 294: E961-E968, 2008. First published March 18, 2008; doi:10.1152/ajpendo.00678.2007 [Abstract] [Full Text] [PDF]

Maja Stefanovic-Racic, German Perdomo, Benjamin S. Mantell, Ian J. Sipula, Nicholas F. Brown, and Robert M. O'Doherty: A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels
Am J Physiol Endocrinol Metab 294: E969-E977, 2008. First published March 18, 2008; doi:10.1152/ajpendo.00497.2007 [Abstract] [Full Text] [PDF]

Elena Galluccio, PierMarco Piatti, Lorena Citterio, Pietro C. G. Lucotti, Emanuela Setola, Laura Cassina, Matteo Oldani, Ivana Zavaroni, Emanuele Bosi, Antonio Colombo, Ottavio Alfieri, Giorgio Casari, Gerald M. Reaven, and Lucilla D. Monti: Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis
Am J Physiol Endocrinol Metab 294: E978-E986, 2008. First published March 18, 2008; doi:10.1152/ajpendo.00003.2008 [Abstract] [Full Text] [PDF]

REPORTS:

Lina Yang, Hongyan Li, Ting Yu, Haijun Zhao, M. George Cherian, Lu Cai, and Ya Liu: Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications
Am J Physiol Endocrinol Metab 294: E987-E992, 2008. First published March 18, 2008; doi:10.1152/ajpendo.90234.2008 [Abstract] [Full Text] [PDF]

CORRIGENDA:

: Corrigendum
Am J Physiol Endocrinol Metab 294: E993-E993, 2008; doi:10.1152/ajpendo.zh1-5318-corr.2008 [Full Text] [PDF]

Cover Caption:

Cover

Cover: Morphology of and expression of iPLA₂β by pancreatic islets isolated from RIP-iPLA₂β transgenic or wild-type mice as assessed by immunofluorescence microscopy. Sections were probed with antibodies to insulin and glucagon and fluorescent secondary antibodies (FITC conjugated-green for insulin, CY3 conjugated-red for glucagon). From Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA₂ in pancreatic β-cells and in iPLA₂β-null mice. Am J Physiol Endocrinol Metab 294: E217–E229, 2008.