AJP - Endocrinology and Metabolism -- Table of Contents (February 1 2008, 294 [2])

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EDITORIAL FOCUS:

Vincent Poitout: Phospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube
Am J Physiol Endocrinol Metab 294: E214-E216, 2008. First published October 9, 2007; doi:10.1152/ajpendo.00638.2007 [Full Text] [PDF]

Shunzhong Bao, David A. Jacobson, Mary Wohltmann, Alan Bohrer, Wu Jin, Louis H. Philipson, and John Turk: Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA₂β in pancreatic β-cells and in iPLA₂β-null mice
Am J Physiol Endocrinol Metab 294: E217-E229, 2008. First published September 25, 2007; doi:10.1152/ajpendo.00474.2007 [Abstract] [Full Text] [PDF]

ESSAYS ON APS CLASSIC PAPERS:

Marcas M. Bamman: The exercise dose response: key lessons from the past
Am J Physiol Endocrinol Metab 294: E230-E231, 2008. First published December 26, 2007; doi:10.1152/ajpendo.00787.2007 [Full Text] [PDF]

INVITED REVIEWS:

Cédric Moro, Sudip Bajpeyi, and Steven R. Smith: Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity
Am J Physiol Endocrinol Metab 294: E203-E213, 2008. First published November 14, 2007; doi:10.1152/ajpendo.00624.2007 [Abstract] [Full Text] [PDF]

FRONTIERS:

Bernhard Aigner, Birgit Rathkolb, Nadja Herbach, Martin Hrabé de Angelis, Rüdiger Wanke, and Eckhard Wolf: Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects
Am J Physiol Endocrinol Metab 294: E232-E240, 2008. First published December 4, 2007; doi:10.1152/ajpendo.00592.2007 [Abstract] [Full Text] [PDF]

ARTICLES:

Isabelle Plaisance, Christian Morandi, Claire Murigande, and Marijke Brink: TNF- ${alpha}$ increases protein content in C₂C₁₂ and primary myotubes by enhancing protein translation via the TNF-R1, PI3K, and MEK
Am J Physiol Endocrinol Metab 294: E241-E250, 2008. First published October 30, 2007; doi:10.1152/ajpendo.00129.2007 [Abstract] [Full Text] [PDF]

Mikael Bjursell, Anna-Karin Gerdin, Christopher J. Lelliott, Emil Egecioglu, Anders Elmgren, Jan Törnell, Jan Oscarsson, and Mohammad Bohlooly-Y: Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice
Am J Physiol Endocrinol Metab 294: E251-E260, 2008. First published November 20, 2007; doi:10.1152/ajpendo.00401.2007 [Abstract] [Full Text] [PDF]

Sihoon Lee, Ranganath Muniyappa, Xu Yan, Hui Chen, Lilly Q. Yue, Eun-Gyoung Hong, Jason K. Kim, and Michael J. Quon: Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice
Am J Physiol Endocrinol Metab 294: E261-E270, 2008. First published November 14, 2007; doi:10.1152/ajpendo.00676.2007 [Abstract] [Full Text] [PDF]

Michael A. Király, Holly E. Bates, Natalia A. Kaniuk, Jessica T. Y. Yue, John H. Brumell, Stephen G. Matthews, Michael C. Riddell, and Mladen Vranic: Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of β-cell function
Am J Physiol Endocrinol Metab 294: E271-E283, 2008. First published November 20, 2007; doi:10.1152/ajpendo.00476.2007 [Abstract] [Full Text] [PDF]

Robin D. Atkinson, Kimberly R. Coenen, Michelle R. Plummer, Marnie L. Gruen, and Alyssa H. Hasty: Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice
Am J Physiol Endocrinol Metab 294: E284-E290, 2008. First published November 20, 2007; doi:10.1152/ajpendo.00601.2007 [Abstract] [Full Text] [PDF]

Gaëlle Prost, Françoise Bernier-Valentin, Yvonne Munari-Silem, Samia Selmi-Ruby, and Bernard Rousset: Connexin-32 acts as a downregulator of growth of thyroid gland
Am J Physiol Endocrinol Metab 294: E291-E299, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00281.2007 [Abstract] [Full Text] [PDF]

Zhibo An, Catherine A. DiCostanzo, Mary C. Moore, Dale S. Edgerton, Dominique P. Dardevet, Doss W. Neal, and Alan D. Cherrington: Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog
Am J Physiol Endocrinol Metab 294: E300-E306, 2008. First published November 20, 2007; doi:10.1152/ajpendo.00380.2007 [Abstract] [Full Text] [PDF]

Hadar Sharfi and Hagit Eldar-Finkelman: Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH₂-terminal kinase plays a role in hepatic insulin signaling
Am J Physiol Endocrinol Metab 294: E307-E315, 2008. First published November 20, 2007; doi:10.1152/ajpendo.00534.2007 [Abstract] [Full Text] [PDF]

Emma Polkinghorne, Quintin Lau, Gregory J. Cooney, Edward W. Kraegen, and Mark E. Cleasby: Local activation of the I ${kappa}$ K-NF- ${kappa}$ B pathway in muscle does not cause insulin resistance
Am J Physiol Endocrinol Metab 294: E316-E325, 2008. First published November 20, 2007; doi:10.1152/ajpendo.00537.2007 [Abstract] [Full Text] [PDF]

Jin Xu, Li Zhang, Andrew Chou, Tim Allaby, Guy Bélanger, Jerry Radziuk, Bernard J. Jasmin, Takashi Miki, Susumo Seino, and Jean-Marc Renaud: K_ATP channel-deficient pancreatic β-cells are streptozotocin resistant because of lower GLUT2 activity
Am J Physiol Endocrinol Metab 294: E326-E335, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00296.2007 [Abstract] [Full Text] [PDF]

Lauren N. Bell, Liying Cai, Brian H. Johnstone, Dmitry O. Traktuev, Keith L. March, and Robert V. Considine: A central role for hepatocyte growth factor in adipose tissue angiogenesis
Am J Physiol Endocrinol Metab 294: E336-E344, 2008. First published December 11, 2007; doi:10.1152/ajpendo.00272.2007 [Abstract] [Full Text] [PDF]

Yongzhong Wei, James R. Sowers, Suzanne E. Clark, Wenhan Li, Carlos M. Ferrario, and Craig S. Stump: Angiotensin II-induced skeletal muscle insulin resistance mediated by NF- ${kappa}$ B activation via NADPH oxidase
Am J Physiol Endocrinol Metab 294: E345-E351, 2008. First published December 11, 2007; doi:10.1152/ajpendo.00456.2007 [Abstract] [Full Text] [PDF]

Murray D. Mitchell, Timothy A. Sato, Anderson Wang, Jeffrey A. Keelan, Anna P. Ponnampalam, and Michelle Glass: Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CB1-receptor-specific mechanism
Am J Physiol Endocrinol Metab 294: E352-E356, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00495.2007 [Abstract] [Full Text] [PDF]

Pawel Dobrzyn, Harini Sampath, Agnieszka Dobrzyn, Makoto Miyazaki, and James M. Ntambi: Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart
Am J Physiol Endocrinol Metab 294: E357-E364, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00471.2007 [Abstract] [Full Text] [PDF]

Paul J. Rozance, Sean W. Limesand, James S. Barry, Laura D. Brown, Stephanie R. Thorn, Dan LoTurco, Timothy R. H. Regnault, Jacob E. Friedman, and William W. Hay, Jr.: Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1 ${alpha}$ mRNA and phosphorylated CREB in fetal sheep
Am J Physiol Endocrinol Metab 294: E365-E370, 2008. First published December 4, 2007; doi:10.1152/ajpendo.00639.2007 [Abstract] [Full Text] [PDF]

Rikke Krogh-Madsen, Peter Plomgaard, Thorbjorn Akerstrom, Kirsten Møller, Ole Schmitz, and Bente Klarlund Pedersen: Effect of short-term intralipid infusion on the immune response during low-dose endotoxemia in humans
Am J Physiol Endocrinol Metab 294: E371-E379, 2008. First published December 4, 2007; doi:10.1152/ajpendo.00507.2007 [Abstract] [Full Text] [PDF]

Kathryn M. S. Johnson, Dale S. Edgerton, Tiffany Rodewald, Melanie Scott, Ben Farmer, Doss Neal, and Alan D. Cherrington: Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization
Am J Physiol Endocrinol Metab 294: E380-E384, 2008. First published December 4, 2007; doi:10.1152/ajpendo.00642.2007 [Abstract] [Full Text] [PDF]

Sekar Natesampillai, Jason Kerkvliet, Peter C. K. Leung, and Johannes D. Veldhuis: Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells
Am J Physiol Endocrinol Metab 294: E385-E391, 2008. First published December 4, 2007; doi:10.1152/ajpendo.00480.2007 [Abstract] [Full Text] [PDF]

Hans C. Dreyer, Micah J. Drummond, Bart Pennings, Satoshi Fujita, Erin L. Glynn, David L. Chinkes, Shaheen Dhanani, Elena Volpi, and Blake B. Rasmussen: Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
Am J Physiol Endocrinol Metab 294: E392-E400, 2008. First published December 4, 2007; doi:10.1152/ajpendo.00582.2007 [Abstract] [Full Text] [PDF]

Kirsten F. Howlett, Alicia Mathews, Andrew Garnham, and Kei Sakamoto: The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle
Am J Physiol Endocrinol Metab 294: E401-E407, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00542.2007 [Abstract] [Full Text] [PDF]

Kristian Vissing, Sean L. McGee, Carsten Roepstorff, Peter Schjerling, Mark Hargreaves, and Bente Kiens: Effect of sex differences on human MEF2 regulation during endurance exercise
Am J Physiol Endocrinol Metab 294: E408-E415, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00403.2007 [Abstract] [Full Text] [PDF]

Mario Siervo, Gema Frühbeck, Adrian Dixon, Gail R. Goldberg, W. Andy Coward, Peter R. Murgatroyd, Andrew M. Prentice, and Susan A. Jebb: Efficiency of autoregulatory homeostatic responses to imposed caloric excess in lean men
Am J Physiol Endocrinol Metab 294: E416-E424, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00573.2007 [Abstract] [Full Text] [PDF]

Sarah L. Wakefield, Michelle Lane, Samantha J. Schulz, Michelle L. Hebart, Jeremy G. Thompson, and Megan Mitchell: Maternal supply of omega-3 polyunsaturated fatty acids alter mechanisms involved in oocyte and early embryo development in the mouse
Am J Physiol Endocrinol Metab 294: E425-E434, 2008. First published December 11, 2007; doi:10.1152/ajpendo.00409.2007 [Abstract] [Full Text] [PDF]

Peter D. Metcalfe, Jeffrey A. Leslie, Matthew T. Campbell, Daniel R. Meldrum, Karen L. Hile, and Kirstan K. Meldrum: Testosterone exacerbates obstructive renal injury by stimulating TNF- ${alpha}$ production and increasing proapoptotic and profibrotic signaling
Am J Physiol Endocrinol Metab 294: E435-E443, 2008. First published December 11, 2007; doi:10.1152/ajpendo.00704.2006 [Abstract] [Full Text] [PDF]

David M. Mott, Karen Stone, Mary C. Gessel, Joy C. Bunt, and Clifton Bogardus: Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes
Am J Physiol Endocrinol Metab 294: E444-E450, 2008. First published December 4, 2007; doi:10.1152/ajpendo.00386.2007 [Abstract] [Full Text] [PDF]

Francine H. Einstein, Sigal Fishman, Radhika H. Muzumdar, Xiao Man Yang, Gil Atzmon, and Nir Barzilai: Accretion of visceral fat and hepatic insulin resistance in pregnant rats
Am J Physiol Endocrinol Metab 294: E451-E455, 2008. First published December 11, 2007; doi:10.1152/ajpendo.00570.2007 [Abstract] [Full Text] [PDF]

Andreas D. Flouris, Giorgos S. Metsios, Athanasios Z. Jamurtas, and Yiannis Koutedakis: Sexual dimorphism in the acute effects of secondhand smoke on thyroid hormone secretion, inflammatory markers and vascular function
Am J Physiol Endocrinol Metab 294: E456-E462, 2008. First published December 11, 2007; doi:10.1152/ajpendo.00699.2007 [Abstract] [Full Text] [PDF]

Lotte Leick, Jørgen F. P. Wojtaszewski, Sune T. Johansen, Kristian Kiilerich, Gemma Comes, Ylva Hellsten, Juan Hidalgo, and Henriette Pilegaard: PGC-1 ${alpha}$ is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle
Am J Physiol Endocrinol Metab 294: E463-E474, 2008. First published December 11, 2007; doi:10.1152/ajpendo.00666.2007 [Abstract] [Full Text] [PDF]

TRANSLATIONAL PHYSIOLOGY:

Mahroukh Rafii, Jane M. McKenzie, Susan A. Roberts, George Steiner, Ronald O. Ball, and Paul B. Pencharz: In vivo regulation of phenylalanine hydroxylation to tyrosine, studied using enrichment in apoB-100
Am J Physiol Endocrinol Metab 294: E475-E479, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00604.2007 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Cover: Morphology of and expression of iPLA₂β by pancreatic islets isolated from RIP-iPLA₂β transgenic or wild-type mice as assessed by immunofluorescence microscopy. Sections were probed with antibodies to insulin and glucagon and fluorescent secondary antibodies (FITC conjugated-green for insulin, CY3 conjugated-red for glucagon). From Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA₂ in pancreatic β-cells and in iPLA₂β-null mice. Am J Physiol Endocrinol Metab 294: E217–E229, 2008.