AJP - Endocrinology and Metabolism -- Table of Contents (July 1 2007, 293 [1])

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ARTICLES:

Claudio Cobelli, Gianna Maria Toffolo, Chiara Dalla Man, Marco Campioni, Paolo Denti, Andrea Caumo, Peter Butler, and Robert Rizza: Assessment of $beta$ -cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests
Am J Physiol Endocrinol Metab 293: E1-E15, 2007. First published March 6, 2007; doi:10.1152/ajpendo.00421.2006 [Abstract] [Full Text] [PDF]

Kaei Nasu, Masakazu Nishida, Tami Ueda, Akitoshi Yuge, Noriyuki Takai, and Hisashi Narahara: Application of the nuclear factor- ${kappa}$ B inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study
Am J Physiol Endocrinol Metab 293: E16-E23, 2007. First published August 8, 2006; doi:10.1152/ajpendo.00135.2006 [Abstract] [Full Text] [PDF]

Anne Liese Magnusson-Olsson, Susanne Lager, Bo Jacobsson, Thomas Jansson, and Theresa L. Powell: Effect of maternal triglycerides and free fatty acids on placental LPL in cultured primary trophoblast cells and in a case of maternal LPL deficiency
Am J Physiol Endocrinol Metab 293: E24-E30, 2007. First published February 13, 2007; doi:10.1152/ajpendo.00571.2006 [Abstract] [Full Text] [PDF]

Robert C. Noland, John P. Thyfault, Sarah T. Henes, Brian R. Whitfield, Tracey L. Woodlief, Jasper R. Evans, Jennifer A. Lust, Steven L. Britton, Lauren G. Koch, Ronald W. Dudek, G. Lynis Dohm, Ronald N. Cortright, and Robert M. Lust: Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance
Am J Physiol Endocrinol Metab 293: E31-E41, 2007. First published March 6, 2007; doi:10.1152/ajpendo.00500.2006 [Abstract] [Full Text] [PDF]

Jaak Jürimäe and Toivo Jürimäe: Plasma adiponectin concentration in healthy pre- and postmenopausal women: relationship with body composition, bone mineral, and metabolic variables
Am J Physiol Endocrinol Metab 293: E42-E47, 2007. First published March 6, 2007; doi:10.1152/ajpendo.00610.2006 [Abstract] [Full Text] [PDF]

J. Jason Collier, Pili Zhang, Kim B. Pedersen, Susan J. Burke, John W. Haycock, and Donald K. Scott: c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells
Am J Physiol Endocrinol Metab 293: E48-E56, 2007. First published March 6, 2007; doi:10.1152/ajpendo.00357.2006 [Abstract] [Full Text] [PDF]

Fanfan Zhou, Mei Hong, and Guofeng You: Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells
Am J Physiol Endocrinol Metab 293: E57-E61, 2007. First published March 6, 2007; doi:10.1152/ajpendo.00696.2006 [Abstract] [Full Text] [PDF]

John E. Dominy, Jr., Jesse Hwang, and Martha H. Stipanuk: Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells
Am J Physiol Endocrinol Metab 293: E62-E69, 2007. First published February 27, 2007; doi:10.1152/ajpendo.00053.2007 [Abstract] [Full Text] [PDF]

Philip D. Miles, Kai Treuner, Marc Latronica, Jerrold M. Olefsky, and Carrolee Barlow: Impaired insulin secretion in a mouse model of ataxia telangiectasia
Am J Physiol Endocrinol Metab 293: E70-E74, 2007. First published March 13, 2007; doi:10.1152/ajpendo.00259.2006 [Abstract] [Full Text] [PDF]

M. J. De Blasio, M. Dodic, A. J. Jefferies, K. M. Moritz, E. M. Wintour, and J. A. Owens: Maternal exposure to dexamethasone or cortisol in early pregnancy differentially alters insulin secretion and glucose homeostasis in adult male sheep offspring
Am J Physiol Endocrinol Metab 293: E75-E82, 2007. First published March 13, 2007; doi:10.1152/ajpendo.00689.2006 [Abstract] [Full Text] [PDF]

Kerry L. Mullen, Angela C. Smith, Kathryn A. Junkin, and David J. Dyck: Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats
Am J Physiol Endocrinol Metab 293: E83-E90, 2007. First published March 13, 2007; doi:10.1152/ajpendo.00545.2006 [Abstract] [Full Text] [PDF]

Anne Zanchi, Abdul G. Dulloo, Christine Perregaux, Jean-Pierre Montani, and Michel Burnier: Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing properties
Am J Physiol Endocrinol Metab 293: E91-E95, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00024.2007 [Abstract] [Full Text] [PDF]

Satoshi Fujita, MaryAnn Bohland, Graciela Sanchez-Watts, Alan G. Watts, and Casey M. Donovan: Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons
Am J Physiol Endocrinol Metab 293: E96-E101, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00415.2006 [Abstract] [Full Text] [PDF]

Janet Lo, L. Elizabeth Bernstein, Bridget Canavan, Martin Torriani, Malaka B. Jackson, Rexford S. Ahima, and Steven K. Grinspoon: Effects of TNF- ${alpha}$ neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome
Am J Physiol Endocrinol Metab 293: E102-E109, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00089.2007 [Abstract] [Full Text] [PDF]

Ji Young Kim, Kristin Tillison, Shengli Zhou, Yu Wu, and Cynthia M. Smas: The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissue
Am J Physiol Endocrinol Metab 293: E110-E120, 2007. First published March 13, 2007; doi:10.1152/ajpendo.00404.2006 [Abstract] [Full Text] [PDF]

Michelle Lee, Andrea Kim, Streamson C. Chua, Jr., Silvana Obici, and Sharon L. Wardlaw: Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet
Am J Physiol Endocrinol Metab 293: E121-E131, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00555.2006 [Abstract] [Full Text] [PDF]

Geun-Shik Lee and Eui-Bae Jeung: Uterine TRPV6 expression during the estrous cycle and pregnancy in a mouse model
Am J Physiol Endocrinol Metab 293: E132-E138, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00666.2006 [Abstract] [Full Text] [PDF]

Max Bielohuby, Nadja Herbach, Rüdiger Wanke, Christiane Maser-Gluth, Felix Beuschlein, Eckhard Wolf, and Andreas Hoeflich: Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment
Am J Physiol Endocrinol Metab 293: E139-E146, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00705.2006 [Abstract] [Full Text] [PDF]

Ruijin Shao, Birgitta Weijdegård, Julia Fernandez-Rodriguez, Emil Egecioglu, Changlian Zhu, Niklas Andersson, Ann Thurin-Kjellberg, Christina Bergh, and Håkan Billig: Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor- $beta$ 2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo
Am J Physiol Endocrinol Metab 293: E147-E158, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00101.2007 [Abstract] [Full Text] [PDF]

Angela R. Subauste and Charles F. Burant: Role of FoxO1 in FFA-induced oxidative stress in adipocytes
Am J Physiol Endocrinol Metab 293: E159-E164, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00629.2006 [Abstract] [Full Text] [PDF]

Christopher D. Morrison, Xiaochun Xi, Christy L. White, Jianping Ye, and Roy J. Martin: Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism
Am J Physiol Endocrinol Metab 293: E165-E171, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00675.2006 [Abstract] [Full Text] [PDF]

Angela C. Smith, Kerry L. Mullen, Kathryn A. Junkin, Jennifer Nickerson, Adrian Chabowski, Arend Bonen, and David J. Dyck: Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia
Am J Physiol Endocrinol Metab 293: E172-E181, 2007. First published March 20, 2007; doi:10.1152/ajpendo.00677.2006 [Abstract] [Full Text] [PDF]

Rodolfo G. Goya, Paula C. Reggiani, Silvan M. Vesenbeckh, Jean M. Pléau, Yolanda E. Sosa, Gloria M. Cónsole, Rüdiger Schade, Peter Henklein, and Mireille Dardenne: Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice
Am J Physiol Endocrinol Metab 293: E182-E187, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00085.2007 [Abstract] [Full Text] [PDF]

Thomas C. Vary, Joshua C. Anthony, Leonard S. Jefferson, Scot R. Kimball, and Christopher J. Lynch: Rapamycin blunts nutrient stimulation of eIF4G, but not PKC ${varepsilon}$ phosphorylation, in skeletal muscle
Am J Physiol Endocrinol Metab 293: E188-E196, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00037.2007 [Abstract] [Full Text] [PDF]

Luigi Fontana, Dennis T. Villareal, Edward P. Weiss, Susan B. Racette, Karen Steger-May, Samuel Klein, John O. Holloszy and the Washington University School of Medicine CALERIE Group: Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial
Am J Physiol Endocrinol Metab 293: E197-E202, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00102.2007 [Abstract] [Full Text] [PDF]

Zhi Hua Huang, Raul M. Luque, Rhonda D. Kineman, and Theodore Mazzone: Nutritional regulation of adipose tissue apolipoprotein E expression
Am J Physiol Endocrinol Metab 293: E203-E209, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00118.2007 [Abstract] [Full Text] [PDF]

Shuichi Otabe, Xiaohong Yuan, Tomoka Fukutani, Nobuhiko Wada, Toshihiko Hashinaga, Hitomi Nakayama, Naotoshi Hirota, Masayasu Kojima, and Kentaro Yamada: Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet
Am J Physiol Endocrinol Metab 293: E210-E218, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00645.2006 [Abstract] [Full Text] [PDF]

Wei Liao, M. T. Audrey Nguyen, Takeshi Yoshizaki, Svetlana Favelyukis, David Patsouris, Takeshi Imamura, Inder M. Verma, and Jerrold M. Olefsky: Suppression of PPAR- ${gamma}$ attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes
Am J Physiol Endocrinol Metab 293: E219-E227, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00695.2006 [Abstract] [Full Text] [PDF]

Junying Han, Jianxiang Xu, Yun Shi Long, Paul N. Epstein, and Ye Q. Liu: Rat maternal diabetes impairs pancreatic $beta$ -cell function in the offspring
Am J Physiol Endocrinol Metab 293: E228-E236, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00479.2006 [Abstract] [Full Text] [PDF]

Bernard R. Landau, Chandra L. Spring-Robinson, Raymond F. Muzic, Jr., Nadia Rachdaoui, Darrell Rubin, Marc S. Berridge, William C. Schumann, Visvanathan Chandramouli, Timothy S. Kern, and Faramarz Ismail-Beigi: 6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport
Am J Physiol Endocrinol Metab 293: E237-E245, 2007. First published April 3, 2007; doi:10.1152/ajpendo.00022.2007 [Abstract] [Full Text] [PDF]

J. Polak, C. Moro, E. Klimcakova, M. Kovacikova, M. Bajzova, M. Vitkova, Z. Kovacova, R. Sotornik, M. Berlan, N. Viguerie, D. Langin, and V. Stich: The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients
Am J Physiol Endocrinol Metab 293: E246-E251, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00688.2006 [Abstract] [Full Text] [PDF]

Gang Li, Yi Zhang, Enda Rodrigues, DongHang Zheng, Michael Matheny, Kit-Yan Cheng, and Philip J. Scarpace: Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss
Am J Physiol Endocrinol Metab 293: E252-E258, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00451.2006 [Abstract] [Full Text] [PDF]

Alena A. Zalutskaya, Maya Arai, George S. Bounoutas, and Abdul B. Abou-Samra: Impaired adaptation to repeated restraint and decreased response to cold in urocortin 1 knockout mice
Am J Physiol Endocrinol Metab 293: E259-E263, 2007. First published April 24, 2007; doi:10.1152/ajpendo.00616.2006 [Abstract] [Full Text] [PDF]

Juraj Koska, Emilio Ortega, Clifton Bogardus, Jonathan Krakoff, and Joy C. Bunt: The effect of insulin on net lipid oxidation predicts worsening of insulin resistance and development of type 2 diabetes mellitus
Am J Physiol Endocrinol Metab 293: E264-E269, 2007; doi:10.1152/ajpendo.00662.2006 [Abstract] [Full Text] [PDF]

Nancy I. Williams, Sarah L. Berga, and Judy L. Cameron: Synergism between psychosocial and metabolic stressors: impact on reproductive function in cynomolgus monkeys
Am J Physiol Endocrinol Metab 293: E270-E276, 2007. First published April 3, 2007; doi:10.1152/ajpendo.00108.2007 [Abstract] [Full Text] [PDF]

Laura L. Burger, Daniel J. Haisenleder, Gordon M. Wotton, Kevin W. Aylor, Alan C. Dalkin, and John C. Marshall: The regulation of FSH $beta$ transcription by gonadal steroids: testosterone and estradiol modulation of the activin intracellular signaling pathway
Am J Physiol Endocrinol Metab 293: E277-E285, 2007. First published April 3, 2007; doi:10.1152/ajpendo.00447.2006 [Abstract] [Full Text] [PDF]

Thomas E. Jensen, Adam J. Rose, Ylva Hellsten, Jørgen F. P. Wojtaszewski, and Erik A. Richter: Caffeine-induced Ca²⁺ release increases AMPK-dependent glucose uptake in rodent soleus muscle
Am J Physiol Endocrinol Metab 293: E286-E292, 2007. First published April 3, 2007; doi:10.1152/ajpendo.00693.2006 [Abstract] [Full Text] [PDF]

Xuehui Geng, Lehong Li, Rita Bottino, A. N. Balamurugan, Suzanne Bertera, Erik Densmore, Anjey Su, Yigang Chang, Massimo Trucco, and Peter Drain: Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane K_ATP channels
Am J Physiol Endocrinol Metab 293: E293-E301, 2007. First published April 3, 2007; doi:10.1152/ajpendo.00016.2007 [Abstract] [Full Text] [PDF]

P. J. D. Delhanty, P. M. van Koetsveld, C. Gauna, B. van de Zande, G. Vitale, L. J. Hofland, and A. J. van der Lely: Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway
Am J Physiol Endocrinol Metab 293: E302-E309, 2007. First published April 3, 2007; doi:10.1152/ajpendo.00377.2006 [Abstract] [Full Text] [PDF]

D. I. Spratt, M. Frohnauer, H. Cyr-Alves, R. S. Kramer, F. L. Lucas, J. R. Morton, D. F. Cox, K. Becker, and J. T. Devlin: Physiological effects of nonthyroidal illness syndrome in patients after cardiac surgery
Am J Physiol Endocrinol Metab 293: E310-E315, 2007. First published April 10, 2007; doi:10.1152/ajpendo.00687.2006 [Abstract] [Full Text] [PDF]

Haifei Shi, April D. Strader, Stephen C. Woods, and Randy J. Seeley: Sexually dimorphic responses to fat loss after caloric restriction or surgical lipectomy
Am J Physiol Endocrinol Metab 293: E316-E326, 2007. First published April 10, 2007; doi:10.1152/ajpendo.00710.2006 [Abstract] [Full Text] [PDF]

You-Ree Cho, Hyo-Jeong Kim, So-Young Park, Hwi Jin Ko, Eun-Gyoung Hong, Takamasa Higashimori, Zhiyou Zhang, Dae Young Jung, M. Shamsul Ola, Kathryn F. LaNoue, Edward H. Leiter, and Jason. K. Kim: Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes
Am J Physiol Endocrinol Metab 293: E327-E336, 2007; doi:10.1152/ajpendo.00376.2006 [Abstract] [Full Text] [PDF]

Mohan R. Dasu, Sridevi Devaraj, and Ishwarlal Jialal: High glucose induces IL-1 $beta$ expression in human monocytes: mechanistic insights
Am J Physiol Endocrinol Metab 293: E337-E346, 2007. First published April 10, 2007; doi:10.1152/ajpendo.00718.2006 [Abstract] [Full Text] [PDF]

W. Gartner, G. Vila, T. Daneva, A. Nabokikh, F. Koc-Saral, A. Ilhan, O. Majdic, A. Luger, and L. Wagner: New functional aspects of the neuroendocrine marker secretagogin based on the characterization of its rat homolog
Am J Physiol Endocrinol Metab 293: E347-E354, 2007. First published April 10, 2007; doi:10.1152/ajpendo.00055.2007 [Abstract] [Full Text] [PDF]

Adam Whaley-Connell, Gurushankar Govindarajan, Javad Habibi, Melvin R. Hayden, Shawna A. Cooper, Yongzhong Wei, Lixin Ma, Mahnaz Qazi, Daniel Link, Poorna R. Karuparthi, Craig Stump, Carlos Ferrario, and James R. Sowers: Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat
Am J Physiol Endocrinol Metab 293: E355-E363, 2007. First published April 17, 2007; doi:10.1152/ajpendo.00632.2006 [Abstract] [Full Text] [PDF]

Klara Sjögren, Kin-Chuen Leung, Warren Kaplan, Margaret Gardiner-Garden, James Gibney, and Ken K. Y. Ho: Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary men
Am J Physiol Endocrinol Metab 293: E364-E371, 2007. First published April 24, 2007; doi:10.1152/ajpendo.00054.2007 [Abstract] [Full Text] [PDF] [Supplemental Table]

Walailuk Jantarajit, Narongrit Thongon, Jantarima Pandaranandaka, Jarinthorn Teerapornpuntakit, Nateetip Krishnamra, and Narattaphol Charoenphandhu: Prolactin-stimulated transepithelial calcium transport in duodenum and Caco-2 monolayer are mediated by the phosphoinositide 3-kinase pathway
Am J Physiol Endocrinol Metab 293: E372-E384, 2007. First published May 8, 2007; doi:10.1152/ajpendo.00142.2007 [Abstract] [Full Text] [PDF]

K. E. Scholz-Ahrens, G. Delling, B. Stampa, A. Helfenstein, H.-J. Hahne, Y. Açil, W. Timm, R. Barkmann, J. Hassenpflug, J. Schrezenmeir, and C.-C. Glüer: Glucocorticosteroid-induced osteoporosis in adult primiparous Göttingen miniature pigs: effects on bone mineral and mineral metabolism
Am J Physiol Endocrinol Metab 293: E385-E395, 2007. First published April 24, 2007; doi:10.1152/ajpendo.00627.2006 [Abstract] [Full Text] [PDF]

Alessandro Bertuzzi, Serenella Salinari, and Geltrude Mingrone: Insulin granule trafficking in $beta$ -cells: mathematical model of glucose-induced insulin secretion
Am J Physiol Endocrinol Metab 293: E396-E409, 2007. First published April 24, 2007; doi:10.1152/ajpendo.00647.2006 [Abstract] [Full Text] [PDF]

Satsuki Takeuchi, Naoki Mukai, Tetsuya Tateishi, and Shumpei Miyakawa: Production of sex steroid hormones from DHEA in articular chondrocyte of rats
Am J Physiol Endocrinol Metab 293: E410-E415, 2007. First published May 1, 2007; doi:10.1152/ajpendo.00042.2007 [Abstract] [Full Text] [PDF]

Jean-Michel Petit, Anne Minello, Laurence Duvillard, Valérie Jooste, Serge Monier, Véronique Texier, Jean-Baptiste Bour, Alix Poussier, Philippe Gambert, Bruno Verges, and Patrick Hillon: Cell surface expression of LDL receptor in chronic hepatitis C: correlation with viral load
Am J Physiol Endocrinol Metab 293: E416-E420, 2007. First published May 1, 2007; doi:10.1152/ajpendo.00091.2007 [Abstract] [Full Text] [PDF]

Valerie B. O'Leary, Ashley E. Jorett, Christine M. Marchetti, Frank Gonzalez, Susan A. Phillips, Theodore P. Ciaraldi, and John P. Kirwan: Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults
Am J Physiol Endocrinol Metab 293: E421-E427, 2007. First published May 8, 2007; doi:10.1152/ajpendo.00123.2007 [Abstract] [Full Text] [PDF]

TRANSLATIONAL PHYSIOLOGY:

Koichiro Azuma, Leonie K. Heilbronn, Jeanine B. Albu, Steven R. Smith, Eric Ravussin, David E. Kelley and the Look AHEAD Adipose Research Group: Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus
Am J Physiol Endocrinol Metab 293: E435-E442, 2007. First published April 17, 2007; doi:10.1152/ajpendo.00394.2006 [Abstract] [Full Text] [PDF]

INNOVATIVE METHODOLOGY:

K. De Bock, T. Dresselaers, B. Kiens, E. A. Richter, P. Van Hecke, and P. Hespel: Evaluation of intramyocellular lipid breakdown during exercise by biochemical assay, NMR spectroscopy, and Oil Red O staining
Am J Physiol Endocrinol Metab 293: E428-E434, 2007. First published April 10, 2007; doi:10.1152/ajpendo.00112.2007 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Cover: Perivascular fibrosis in the transgenic (mRen2) 27 (Ren2) heart. Light microscopic image at ×40 of structural changes in left ventricle of the placebo-treated Ren2 control, an animal model of chronically elevated tissue of angiotensin II and renin-angiotensis system activation. The image depicts perivascular fibrosis, using VVG (Verhoeff-van Gieson) staining; the Verhoeff component of this two-part stain is specific for elastin fibers, whereas the van Gieson stain is specific for collagen. From Whaley-Connell A, Govindarajan G, Habibi J, Hayden MR, Cooper SA, Wei Y, Ma L, Qazi M, Link D, Karuparthi PR, Stump C, Ferrario C, Sowers JR. Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat. Am J Physiol Endocrinol Metab 293: E355�E363, 2007.