We are unable to reproduce a finding published in this Journal (1). Briefly, in that study we investigated generation 16 (G16) of an artificially selected phenotype of rats bred for low- or high-aerobic running capacity. In our paper, we report on dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity. We now have unequivocal evidence that there is no such dysregulation. Since publication, we have analyzed muscle lipids from generation 21 (G21) of this animal line. To our surprise, the lipid data from G21 animals were inconsistent with those that we had reported previously for G16 animals. This alerted us to a potential problem with our original data arising from G16 animals. Accordingly, we reanalyzed red quadriceps muscle from G16 animals. We could not replicate the lipid data that we originally reported for muscle triglyceride, diacylglycerol, and ceramide content or FAT/CD36. We therefore wish to retract a central observation in that paper.
We wish to stress that there is absolutely no reason to question any of the remaining data in the paper, all of which were undertaken by our collaborators in their various laboratories. However, as the title of the paper and the discussion is based on a false premise (i.e., there is no dysregulation of lipid metabolism), we consider a retraction of the entire paper to be in the best interests of the scientific community. We will publish the results of our current study when they are completed. We regret this error.
- Copyright © 2007 by American Physiological Society