AJP - Endo AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab (January 13, 2009). doi:10.1152/ajpendo.90903.2008
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
296/4/E621    most recent
90903.2008v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Andrews, Z. B
Right arrow Articles by Horvath, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andrews, Z. B
Right arrow Articles by Horvath, T.
Submitted on November 10, 2008
Revised on December 12, 2008
Accepted on December 31, 2008

Uncoupling Protein 2 regulates lifespan in mice

Zane B Andrews1 and Tamas Horvath2*

1 Monash University
2 Yale

* To whom correspondence should be addressed. E-mail: tamas.horvath{at}yale.edu.

The long-term effects of uncoupled mitochondrial respiration by uncoupling protein 2 (UCP2) in mammalian physiology remains controversial. Here we show that increased mitochondrial uncoupling activity of different tissues predicts longer lifespan of rats compared to mice. UCP2 reduces reactive oxygen species (ROS) production and oxidative stress throughout the aging process in different tissues in mice. The absence of UCP2 shortens life span in wild type mice, and, the level of UCP2 positively correlates with the postnatal survival of superoxide dismutase 2 mutant animals. Thus, UCP2 has a beneficial influence on cell and tissue function leading to increased lifespan.




This article has been cited by other articles:


Home page
 PhysiologyHome page
Highlights From The Literature
Physiology, June 1, 2009; 24(3): 144 - 146.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. H. Lockie, T. D. Muller, and M. H. Tschop
Coupled with uncouplers: the curious case of lifespan
Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E619 - E620.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2009 by the American Physiological Society.