AJP - Endo Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab (June 24, 2008). doi:10.1152/ajpendo.90481.2008
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
295/2/E491    most recent
90481.2008v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lam, C. K.L.
Right arrow Articles by Lam, T. K.T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lam, C. K.L.
Right arrow Articles by Lam, T. K.T.
Submitted on May 30, 2008
Revised on June 16, 2008
Accepted on June 17, 2008

Central Lactate Metabolism Regulates Food Intake

Carol K.L. Lam, Madhu Chari, Penny Y.T. Wang, and Tony K.T. Lam1*

1 University Health Network & University of Toronto

* To whom correspondence should be addressed. E-mail: tony.lam{at}uhnres.utoronto.ca.

Central nervous system regulates food intake (FI) and body weight (BW), but the associated mechanisms remain to be elucidated. Here we report that central injections of lactate reduced FI and BW in rodents. Inhibition of central lactate metabolism to pyruvate with lactate dehydrogenase inhibitor oxamate abolished the central effects of lactate on FI and BW. Conversely, central injections of pyruvate recapitulated the effects of lactate. Finally, inhibition of central lactate metabolism prevented the ability of circulating lactate to lower FI and BW. Together, the data indicate that activation of central lactate metabolism lowers FI and BW.




This article has been cited by other articles:


Home page
 J ANIM SCIHome page
M. S. Allen, B. J. Bradford, and M. Oba
BOARD-INVITED REVIEW: The hepatic oxidation theory of the control of feed intake and its application to ruminants
J Anim Sci, October 1, 2009; 87(10): 3317 - 3334.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
C. K. L. Lam, M. Chari, and T. K. T. Lam
CNS Regulation of Glucose Homeostasis
Physiology, June 1, 2009; 24(3): 159 - 170.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2008 by the American Physiological Society.