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This Article Full Text Full Text (PDF) All Versions of this Article: 293/6/E1670    most recent 00287.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Brunner, S. Articles by Franz, W.-M. Search for Related Content PubMed PubMed Citation Articles by Brunner, S. Articles by Franz, W.-M.

Primary hyperparathyroidism is associated with increased circulating bone marrow-derived progenitor cells

¹Klinikum Grosshadern, Medical Department I, Ludwig-Maximilians University; and ²Department of Surgery, Krankenhaus Martha-Maria, Munich, Germany

Submitted 9 May 2007 ; accepted in final form 27 September 2007

Recently, parathyroid hormone (PTH) was shown to support survival of progenitor cells in bone marrow. The release of progenitor cells occurs in physiological and pathological conditions and was shown to contribute to neovascularization in tumors and ischemic tissues. In the present study we sought to investigate prospectively the effect of primary hyperparathyroidism (PHPT) on mobilization of bone marrow-derived progenitor cells. In 22 patients with PHPT and 10 controls, defined subpopulations of circulating bone marrow-derived progenitor cells (BMCs) were analyzed by flow cytometry (CD45⁺/CD34⁺/CD31⁺ cells indicating endothelial progenitor cells, CD45⁺/CD34⁺/c-kit⁺ cells indicating hematopoietic stem cells, and CD45⁺/CD34⁺/CXCR4⁺ cells indicating progenitor cells with the homing receptor CXCR4). Cytokine serum levels (SCF, SDF-1, VEGF, EPO, and G-CSF) were assessed using ELISA. Levels of PTH and thyroid hormone as well as serum electrolytes, renal and liver parameters, and blood count were analyzed. Our data show for the first time a significant increase of circulating BMCs and an upregulation of SDF-1 and VEGF serum levels in patients with PHPT. The number of circulating BMCs returned to control levels measured 16.7 ± 2.3 mo after surgery. There was a positive correlation of PTH levels with the number of CD45⁺/CD34⁺/CD31⁺, CD45⁺/CD34⁺/c-kit⁺, and CD45⁺/CD34⁺/CXCR4⁺ cells. However, there was no correlation between cytokine serum concentrations (SDF-1, VEGF) and circulating BMCs. Serum levels of G-CSF, EPO, and SCF known to mobilize BMCs were even decreased or remained unchanged, suggesting a direct effect of PTH on stem cell mobilization. Our data suggest a new function of PTH mobilizing BMCs into peripheral blood.

parathyroid hormone; mobilization; cytokines

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