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Am J Physiol Endocrinol Metab 293: E228-E236, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00479.2006
0193-1849/07 $8.00
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Rat maternal diabetes impairs pancreatic beta-cell function in the offspring

Junying Han,1,* Jianxiang Xu,1,* Yun Shi Long,1 Paul N. Epstein,1,2 and Ye Q. Liu1,2

1Kosair Children's Hospital Research Institute, Department of Pediatrics and 2Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky

Submitted 7 September 2006 ; accepted in final form 20 March 2007

It has been shown that maternal diabetes increases the risk for obesity, glucose intolerance, and Type 2 diabetes mellitus in the adult life of the offspring. Mechanisms for these effects on the offspring are not well understood, and little information is available to reveal the mechanisms. We studied the effect of maternal diabetes on beta-cell function in the offspring of streptozotocin (STZ)-induced diabetic rat mothers (STZ-offspring). STZ-offspring did not become glucose intolerant up to 15 wk of age. At this age, however, insulin secretion was significantly impaired, as measured by in vivo and in vitro studies. Consistent with these changes, islet glucose metabolism and some important glucose metabolic enzyme activities were reduced. No significant changes were found in islet morphological analysis. These data indicate that beta-cell function is impaired in adult STZ-offspring; these changes may contribute to the development of type 2 diabetes mellitus in adulthood.

insulin secretion; islets of Langerhans; type 2 diabetes mellitus


Address for reprint requests and other correspondence: Y. Q. Liu, Kosair Children's Hospital Research Institute, Dept. of Pediatrics, Univ. of Louisville College of Medicine, 570 South Preston St., Suite 304, Louisville, KY 40202 (e-mail: yqliu001{at}gwise.louisville.edu)






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