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Am J Physiol Endocrinol Metab 291: E1243-E1249, 2006. First published July 11, 2006; doi:10.1152/ajpendo.00246.2006
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No effect of menstrual cycle phase on basal very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics

Faidon Magkos,1,2 Bruce W. Patterson,1 and Bettina Mittendorfer1

1Washington University School of Medicine, St. Louis, Missouri; and 2Department of Nutrition and Dietetics, Harokopio University, Athens, Greece

Submitted 23 May 2006 ; accepted in final form 6 July 2006

Dyslipidemia, manifested by increased plasma triglyceride (TG), increased total and LDL-cholesterol concentrations and decreased HDL-cholesterol concentration, is an important risk factor for cardiovascular disease. Premenopausal women have a less atherogenic plasma lipid profile and a lower risk of cardiovascular disease than men, but this female advantage disappears after menopause. This suggests that female sex steroids affect lipoprotein metabolism. The impact of variations in the availability of ovarian hormones during the menstrual cycle on lipoprotein metabolism is not known. We therefore investigated whether very-low-density lipoprotein (VLDL)-TG and VLDL-apolipoprotein B-100 (apoB-100) kinetics are different during the follicular (FP) and luteal phases (LP) of the menstrual cycle. We studied seven healthy, premenopausal women (age 27 ± 2 yr, BMI 25 ± 2 kg/m2) once during FP and once during LP. We measured VLDL-TG, VLDL-apoB-100, and plasma free fatty acid (FFA) kinetics by using stable isotope-labeled tracers, VLDL subclass profile by nuclear magnetic resonance spectroscopy, whole body fat oxidation by indirect calorimetry, and the plasma concentrations of lipoprotein lipase (LPL) and hepatic lipase (HL) by ELISA. VLDL-TG and VLDL-apoB-100 concentrations in plasma, VLDL-TG and VLDL-apoB-100 secretion rates and mean residence times, VLDL subclass distribution, FFA concentration and rate of appearance in plasma, whole body substrate oxidation, and LPL and HL concentrations in plasma were not different during the FP and the LP. We conclude that VLDL-TG and VLDL-apoB-100 metabolism is not affected by menstrual cycle phase.

sex hormones; stable isotope; lipid


Address for reprint requests and other correspondence: B. Mittendorfer, Washington University School of Medicine, Div. of Geriatrics & Nutritional Science, 660 S. Euclid Ave., Campus Box 8031, St. Louis, MO 63110 (e-mail: mittendb{at}wustl.edu)




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Home page
 J. Lipid Res.Home page
F. Magkos, B. W. Patterson, and B. Mittendorfer
Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics
J. Lipid Res., May 1, 2007; 48(5): 1204 - 1211.
[Abstract] [Full Text] [PDF]


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