HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 290/2/E326    most recent 00020.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (33) Citing Articles via Google Scholar Google Scholar Articles by Haugen, F. Articles by Drevon, C. A. Search for Related Content PubMed PubMed Citation Articles by Haugen, F. Articles by Drevon, C. A.

Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression

¹Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo; ²Department of Medical Genetics, Rikshospitalet University Hospital; and ³Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway

Submitted 18 January 2005 ; accepted in final form 2 September 2005

Adipokines are predominantly secretory protein hormones from adipose tissue but may also originate in placenta and other organs. Cross-sectionally, we monitored maternal plasma concentration of adiponectin, resistin, and leptin and their mRNA expression in abdominal subcutaneous adipose tissue and placenta from preeclamptic (PE; n = 15) and healthy pregnant (HP; n = 23) women undergoing caesarean section. The study groups were similar in age and BMI, whereas HOMA-IR tended to be higher in the PE group. In fasting plasma samples, the PE group had higher concentrations of adiponectin (18.3 ± 2.2 vs. 12.2 ± 1.1 µg/ml, P = 0.011), resistin (5.68 ± 0.41 vs. 4.65 ± 0.32 ng/ml, P = 0.028), and leptin (34.4 ± 3.2 vs. 22.7 ± 2.1 ng/ml, P = 0.003) compared with the HP group. Adiponectin and leptin concentrations were still different between PE and HP after controlling for BMI and HOMA-IR, whereas resistin concentrations differed only after controlling for BMI but not HOMA-IR. We found similar mean mRNA levels of adiponectin, resistin, and leptin in abdominal subcutaneous adipose tissue in PE and HP women. When data were pooled from PE and HP women, resistin mRNA levels in adipose tissue also correlated with HOMA-IR (r = 0.470, P = 0.012) after controlling for BMI and pregnancy duration. Resistin mRNA levels in placenta were not significantly different between PE and HP, whereas leptin mRNA levels were higher in PE placenta compared with HP. Thus increased plasma concentrations of adiponectin and resistin in preeclampsia may not relate to altered expression levels in adipose tissue and placenta, whereas both plasma and placenta mRNA levels of leptin are increased in preeclampsia.

adiponectin; resistin; leptin; pregnancy

This article has been cited by other articles:

				D. D. Briana and A. Malamitsi-Puchner Reviews: Adipocytokines in Normal and Complicated Pregnancies Reproductive Sciences, October 1, 2009; 16(10): 921 - 937. [Abstract] [PDF]

				Tie Weiwei, Yu Haiyan, Chen Juan, Wang Xiaodong, Chen Weibo, and Zhou Rong Expressions of Adiponectin Receptors in Placenta and Their Correlation With Preeclampsia Reproductive Sciences, July 1, 2009; 16(7): 676 - 684. [Abstract] [PDF]

				F. Herse, Bai Youpeng, A. C. Staff, J. Yong-Meid, R. Dechend, and Zhou Rong Circulating and Uteroplacental Adipocytokine Concentrations in Preeclampsia Reproductive Sciences, June 1, 2009; 16(6): 584 - 590. [Abstract] [PDF]

				M. Fasshauer, T. Waldeyer, J. Seeger, S. Schrey, T. Ebert, J. Kratzsch, U. Lossner, M. Bluher, M. Stumvoll, R. Faber, et al. Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function Eur. J. Endocrinol., February 1, 2008; 158(2): 197 - 201. [Abstract] [Full Text] [PDF]

				R. Troisi, N. Potischman, and R. N. Hoover Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary Cancer Epidemiol. Biomarkers Prev., September 1, 2007; 16(9): 1700 - 1712. [Abstract] [Full Text] [PDF]

				F. Herse, R. Dechend, N. K. Harsem, G. Wallukat, J. Janke, F. Qadri, L. Hering, D. N. Muller, F. C. Luft, and A. C. Staff Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in Preeclampsia Hypertension, March 1, 2007; 49(3): 604 - 611. [Abstract] [Full Text] [PDF]

				D.-M. Alexe, G. Syridou, and E. Th. Petridou Determinants of Early Life Leptin Levels and Later Life Degenerative Outcomes Clin. Med. Res., December 1, 2006; 4(4): 326 - 335. [Abstract] [Full Text] [PDF]