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This Article Full Text Full Text (PDF) All Versions of this Article: 288/4/E768    most recent 00381.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Pietiläinen, K. H. Articles by Yki-Järvinen, H. Search for Related Content PubMed PubMed Citation Articles by Pietiläinen, K. H. Articles by Yki-Järvinen, H.

Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins

¹The Finnish Twin Cohort Study, Department of Public Health, University of Helsinki; ²Obesity Research Unit, Department of Psychiatry, ³Department of Medicine, Division of Diabetes, and ⁴Department of Oncology, Helsinki University Central Hospital; and ⁵Department of Mental Health and Alcohol Research, National Public Health Institute; Helsinki, Finland

Submitted 17 August 2004 ; accepted in final form 23 November 2004

We determined whether acquired obesity is associated with increases in liver or intra-abdominal fat or impaired insulin sensitivity by studying monozygotic (MZ) twin pairs discordant and concordant for obesity. We studied nineteen 24- to 27-yr-old MZ twin pairs, with intrapair differences in body weight ranging from 0.1 to 24.7 kg [body mass index (BMI) range 20.0–33.9 kg/m²], identified from a population-based FinnTwin16 sample. Fat distribution was determined by magnetic resonance imaging, percent body fat by dual-energy X-ray absorptiometry, liver fat by proton spectroscopy, insulin sensitivity by measuring the fasting insulin concentration, and whole body insulin sensitivity by the euglycemic insulin clamp technique. Intrapair differences in BMI were significantly correlated with those in intra-abdominal fat (r = 0.82, P < 0.001) and liver fat (r = 0.57, P = 0.010). Intrapair differences in fasting insulin correlated with those in subcutaneous abdominal (r = 0.60, P = 0.008), intra-abdominal (r = 0.75, P = 0.0001) and liver (r = 0.49, P = 0.048) fat. Intrapair differences in whole body insulin sensitivity correlated with those in subcutaneous abdominal (r = –0.72, P = 0.001) and intra-abdominal (r = –0.55, P = 0.015) but not liver (r = –0.20, P = 0.20) fat. We conclude that acquired obesity is associated with increases in intra-abdominal and liver fat and insulin resistance, independent of genetic factors.

body composition; fatty liver; genes; environment; spectroscopy; magnetic resonance imaging

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