HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/1/E143    most recent 00117.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Fattor, J. A. Articles by Brooks, G. A. Search for Related Content PubMed PubMed Citation Articles by Fattor, J. A. Articles by Brooks, G. A.

Catecholamine response is attenuated during moderate-intensity exercise in response to the "lactate clamp"

Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California

Submitted 9 March 2004 ; accepted in final form 19 August 2004

Catecholamine release is known to be regulated by feedforward and feedback mechanisms. Norepinephrine (NE) and epinephrine (Epi) concentrations rise in response to stresses, such as exercise, that challenge blood glucose homeostasis. The purpose of this study was to assess the hypothesis that the lactate anion is involved in feedback control of catecholamine concentration. Six healthy active men (26 ± 2 yr, 82 ± 2 kg, 50.7 ± 2.1 ml·kg^–1·min^–1) were studied on five occasions after an overnight fast. Plasma concentrations of NE and Epi were determined during 90 min of rest and 90 min of exercise at 55% of peak O₂ consumption (O_{2 peak}) two times with exogenous lactate infusion (lactate clamp, LC) and two times without LC (CON). The blood lactate profile (4 mM) of a preliminary trial at 65% O_{2 peak} (65%) was matched during the subsequent LC trials. In resting men, plasma NE concentration was not different between trials, but during exercise all conditions were different with 65% > CON > LC (65%: 2,115 ± 166 pg/ml, CON: 1,573 ± 153 pg/ml, LC: 930 ± 174 pg/ml, P < 0.05). Plasma Epi concentrations at rest were different between conditions, with LC less than 65% and CON (65%: 68 ± 9 pg/ml, CON: 59 ± 7 pg/ml, LC: 38 ± 10 pg/ml, P < 0.05). During exercise, Epi concentration showed the same trend (65%: 262 ± 37 pg/ml, CON: 190 ± 34 pg/ml, LC: 113.2 ± 23 pg/ml, P < 0.05). In conclusion, lactate attenuates the catecholamine response during moderate-intensity exercise, likely by feedback inhibition.

norepinephrine; epinephrine; exogenous lactate infusion; sympathetic response; fuel sensing

This article has been cited by other articles:

				G. C. Henderson, J. A. Fattor, M. A. Horning, N. Faghihnia, M. L. Johnson, T. L. Mau, M. Luke-Zeitoun, and G. A. Brooks Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period J. Physiol., November 1, 2007; 584(3): 963 - 981. [Abstract] [Full Text] [PDF]

				A. L. Friedlander, K. A. Jacobs, J. A. Fattor, M. A. Horning, T. A. Hagobian, T. A. Bauer, E. E. Wolfel, and G. A. Brooks Contributions of working muscle to whole body lipid metabolism are altered by exercise intensity and training Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E107 - E116. [Abstract] [Full Text] [PDF]