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Am J Physiol Endocrinol Metab 287: E1189-E1194, 2004. First published August 10, 2004; doi:10.1152/ajpendo.00206.2004
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Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle

Christian P. Fischer,1,2 Peter Plomgaard,1,2 Anne K. Hansen,1,2 Henriette Pilegaard,2,3 Bengt Saltin,2 and Bente Klarlund Pedersen1,2

1Department of Infectious Diseases, Rigshospitalet, 2Copenhagen Muscle Research Centre, and 3The August Krogh Institute, University of Copenhagen, 2100 Copenhagen Ø, Denmark

Submitted 13 May 2004 ; accepted in final form 6 August 2004

Contracting skeletal muscle expresses large amounts of IL-6. Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to a less-pronounced increase of skeletal muscle IL-6 mRNA in response to acute exercise. Thus, before and after 10 wk of knee extensor endurance training, skeletal muscle IL-6 mRNA expression was determined in young healthy men (n = 7) in response to 3 h of dynamic knee extensor exercise, using the same relative workload. Maximal power output, time to exhaustion during submaximal exercise, resting muscle glycogen content, and citrate synthase and 3-hydroxyacyl-CoA dehydrogenase enzyme activity were all significantly enhanced by training. IL-6 mRNA expression in resting skeletal muscle did not change in response to training. However, although absolute workload during acute exercise was 44% higher (P < 0.05) after the training period, skeletal muscle IL-6 mRNA content increased 76-fold (P < 0.05) in response to exercise before the training period, but only 8-fold (P < 0.05, relative to rest and pretraining) in response to exercise after training. Furthermore, the exercise-induced increase of plasma IL-6 (P < 0.05, pre- and posttraining) was not higher after training despite higher absolute work intensity. In conclusion, the magnitude of the exercise-induced IL-6 mRNA expression in contracting human skeletal muscle was markedly reduced by 10 wk of training.

cytokines; exercise; glycogen; plasma; skeletal muscle


Address for reprint requests and other correspondence: C. P. Fischer, Dept. of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, Section M7641, DK-2100 Copenhagen, Denmark (E-mail: cfischer{at}dadlnet.dk)




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