| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Department of Medicine, Division of Nephrology, 2Department of Surgery, and 3Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee 37232
Submitted 25 August 2003 ; accepted in final form 9 December 2003
Decreased dietary protein intake and hemodialysis (HD)-associated protein catabolism are among several factors that predispose chronic hemodialysis (CHD) patients to uremic malnutrition and associated muscle wasting. Intradialytic parenteral nutrition (IDPN) acutely reverses the net negative whole body and forearm muscle protein balances observed during the HD procedure. Exercise has been shown to improve muscle protein homeostasis, especially if performed with adequately available intramuscular amino acids. We hypothesized that exercise performance would provide additive anabolic effects to the beneficial effects of IDPN. We studied six CHD patients at two separate HD sessions: 1) IDPN administration only and 2) IDPN + exercise. Patients were studied 2 h before, during, and 2 h after an HD session by use of a primed constant infusion of L-[1-13C]leucine and L-[ring-2H5] phenylalanine. Exercise combined with IDPN promoted additive twofold increases in forearm muscle essential amino acid uptake (455 ± 105 vs. 229 ± 38 nmol·100 ml-1·min-1, P < 0.05) and net muscle protein accretion (125 ± 37 vs. 56 ± 30 µg·100 ml-1·min-1, P < 0.05) during HD compared with IDPN alone. Measurements of whole body protein homeostasis and energy expenditure were not altered by exercise treatment. In conclusion, exercise in the presence of adequate nutritional supplementation has potential as a therapeutic intervention to blunt the loss of muscle mass in CHD patients.
malnutrition; muscle; catabolism
This article has been cited by other articles:
|
|
 |
|
  M. Fischbach, J. Terzic, S. Menouer, C. Dheu, L. Seuge, and A. Zalosczic Daily on line haemodiafiltration promotes catch-up growth in children on chronic dialysis Nephrol. Dial. Transplant., November 4, 2009; (2009) gfp565v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-E. Heng and N. J. M. Cano Nutritional problems in adult patients with stage 5 chronic kidney disease on dialysis (both haemodialysis and peritoneal dialysis) NDT Plus, October 19, 2009; (2009) sfp147v1. [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Fuhrman Intradialytic Parenteral Nutrition and Intraperitoneal Nutrition Nutr Clin Pract, August 1, 2009; 24(4): 470 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Anderson, J. B. Halter, W. R. Hazzard, J. Himmelfarb, F. M. Horne, G. A. Kaysen, J. W. Kusek, S. G. Nayfield, K. Schmader, Y. Tian, et al. Prediction, Progression, and Outcomes of Chronic Kidney Disease in Older Adults J. Am. Soc. Nephrol., June 1, 2009; 20(6): 1199 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Ikizler and J. Himmelfarb Muscle Wasting in Kidney Disease: Let's Get Physical J. Am. Soc. Nephrol., August 1, 2006; 17(8): 2097 - 2098. [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Adams and N. D. Vaziri Skeletal muscle dysfunction in chronic renal failure: effects of exercise Am J Physiol Renal Physiol, April 1, 2006; 290(4): F753 - F761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B Pupim, P. J Flakoll, C. Yu, and T A. Ikizler Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients Am. J. Clinical Nutrition, December 1, 2005; 82(6): 1235 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cuppari, A. B. de Carvalho, C. M. Avesani, M. A. Kamimura, R. R. dos Santos Lobao, and S. A. Draibe Increased Resting Energy Expenditure in Hemodialysis Patients with Severe Hyperparathyroidism J. Am. Soc. Nephrol., November 1, 2004; 15(11): 2933 - 2939. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
