AJP - Endo Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 286: E217-E225, 2004. First published October 14, 2003; doi:10.1152/ajpendo.00159.2003
0193-1849/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
286/2/E217    most recent
00159.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zderic, T. W.
Right arrow Articles by Coyle, E. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zderic, T. W.
Right arrow Articles by Coyle, E. F.

High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise

Theodore W. Zderic,1 Christopher J. Davidson,1 Simon Schenk,1 Lauri O. Byerley,2 and Edward F. Coyle1

1Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas 78712; and 2Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 78080

Submitted 11 April 2003 ; accepted in final form 29 September 2003

This study determined the role of intramuscular triglyceride (IMTG) and adipose lipolysis in the elevated fat oxidation during exercise caused by a high-fat diet. In four separate trials, six endurance-trained cyclists exercised at 50% peak O2 consumption for 1 h after a two-day control diet (22% fat, CON) or an isocaloric high-fat diet (60% fat, HF) with or without the ingestion of acipimox, an adipose lipolysis inhibitor, before exercise. During exercise, HF elevated fat oxidation by 72% and whole body lipolysis [i.e., the appearance rate of glycerol in plasma (Ra glycerol)] by 79% compared with CON (P < 0.05), and this was associated with a 36% increase (P < 0.05) in preexercise IMTG concentration. Although acipimox lowered plasma free fatty acid (FFA) availability, HF still increased fat oxidation and Ra glycerol to the same magnitude above control as the increase caused by HF without acipimox (i.e., both increased fat oxidation 13–14 µmol·kg–1·min–1). In conclusion, the marked increase in fat oxidation after a HF diet is associated with elevated IMTG concentration and whole body lipolysis and does not require increased adipose tissue lipolysis and plasma FFA concentration during exercise. This suggests that altered substrate storage in skeletal muscle is responsible for increased fat oxidation during exercise after 2 days of an HF diet.

lipid; carbohydrate; glycogen; glycerol kinetics


Address for reprint requests and other correspondence: E. F. Coyle, Bellmont Hall 222, Dept. of Kinesiology and Health Education, The Univ. of Texas at Austin, Austin, TX 78712 (E-mail: coyle{at}mail.utexas.edu).




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
W. K. Yeo, S. J. Lessard, Z.-P. Chen, A. P. Garnham, L. M. Burke, D. A. Rivas, B. E. Kemp, and J. A. Hawley
Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
J Appl Physiol, November 1, 2008; 105(5): 1519 - 1526.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. Moro, S. Bajpeyi, and S. R. Smith
Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity
Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E203 - E213.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Stellingwerff, L. L. Spriet, M. J. Watt, N. E. Kimber, M. Hargreaves, J. A. Hawley, and L. M. Burke
Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration
Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E380 - E388.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. Kiens
Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance
Physiol Rev, January 1, 2006; 86(1): 205 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. K. McConell, N. N. Huynh, R. S. Lee-Young, B. J. Canny, and G. D. Wadley
L-Arginine infusion increases glucose clearance during prolonged exercise in humans
Am J Physiol Endocrinol Metab, January 1, 2006; 290(1): E60 - E66.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
B. D. Roorda, M. K. C. Hesselink, G. Schaart, E. Moonen-Kornips, P. Martinez-Martinez, M. Losen, M. H. De Baets, R. P. Mensink, and P. Schrauwen
DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content
J. Lipid Res., February 1, 2005; 46(2): 230 - 236.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. W. Zderic, S. Schenk, C. J. Davidson, L. O. Byerley, and E. F. Coyle
Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by {beta}-adrenergic blockade
Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1195 - E1201.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. J. C. van Loon
Use of intramuscular triacylglycerol as a substrate source during exercise in humans
J Appl Physiol, October 1, 2004; 97(4): 1170 - 1187.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.