HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 285/2/E311    most recent 00490.2002v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Van Pelt, R. E. Articles by Kohrt, W. M. Search for Related Content PubMed PubMed Citation Articles by Van Pelt, R. E. Articles by Kohrt, W. M.

Intravenous estrogens increase insulin clearance and action in postmenopausal women

Department of Medicine, Division of Geriatric Medicine, Center on Aging, University of Colorado Health Sciences Center, Denver, Colorado 80262

Submitted 11 November 2002 ; accepted in final form 2 April 2003

To test the hypothesis that estrogens alter insulin action, we evaluated the effects of intravenous conjugated estrogens (CE) on insulin-stimulated steady-state glucose infusion rate (SSGIR) and suppression of plasma glycerol in postmenopausal women (mean ± SD; 56 ± 4 yr; n = 12) not using hormone replacement. SSGIR and glycerol were measured during a two-stage (8 and 40 mU · m^-2 · min^-1) hyperinsulinemic euglycemic clamp on 2 days, with or without a 2.5-mg intravenous CE bolus. Serum estradiol concentrations were increased 200% on the estrogen (EST) compared with the control (CON) days. Serum insulin was reduced (P < 0.01) during stage 2 of the clamp for EST (63.3 ± 12.8 µU/ml) vs. CON (78.2 ± 15.8 µU/ml). Mean SSGIR and plasma glycerol did not differ between CON and EST days. With adjustment for differences in insulin concentration between conditions, stage 2 glucose disposals were significantly higher (8.63 vs. 7.20 mg · kg^-1 · min^-1) and plasma glycerol concentrations were significantly lower (29.4 vs. 35.0 µmol/l) for EST vs. CON. Our findings suggest that acute CE administration increases insulin clearance and action in postmenopausal women.

euglycemic clamp; lipolysis; conjugated estrogens

This article has been cited by other articles:

				M. J. Toth, B. C. Cooper, R. E. Pratley, A. Mari, D. E. Matthews, and P. R. Casson Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion Am J Physiol Endocrinol Metab, June 1, 2008; 294(6): E1035 - E1045. [Abstract] [Full Text] [PDF]

				M. E. Wierman and W. M. Kohrt Review Article: Vascular and Metabolic Effects of Sex Steroids: New Insights Into Clinical Trials Reproductive Sciences, May 1, 2007; 14(4): 300 - 314. [Abstract] [PDF]

				M. R. Batista, M. S. Smith, W. L. Snead, C. C. Connolly, D. B. Lacy, and M. C. Moore Chronic estradiol and progesterone treatment in conscious dogs: effects on insulin sensitivity and response to hypoglycemia Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1064 - R1073. [Abstract] [Full Text] [PDF]