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Am J Physiol Endocrinol Metab 284: E874-E882, 2003. First published October 15, 2002; doi:10.1152/ajpendo.00209.2002
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Vol. 284, Issue 5, E874-E882, May 2003

Acute alcohol administration inhibits the refeeding response after starvation in rat skeletal muscle

A. A. Sneddon1, M. Koll3, M. C. Wallace2, J. Jones4, J. P. Miell4, P. J. Garlick5, and V. R. Preedy3

1 Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB; 2 Department of Agriculture and Forestry, University of Aberdeen, Aberdeen AB24 5UA; 3 Department of Nutrition and Dietetics, King's College London, London SE1 9NN; and 4 Department of Medicine, Guys, Kings and St. Thomas' School of Medicine, King's Denmark Hill Campus, London SE5 9PJ, United Kingdom; and 5 Department of Surgery, State University of New York at Stony Brook, Stony Brook, New York 11794

This study determined whether an acute alcohol dose could inhibit the refeeding response in starved muscle. Rats starved for 24 h were pretreated with alcohol or saline before refeeding by intragastric or intravenous infusion of enteral diet (ENT), total parenteral nutrition (TPN), or saline. Refeeding by TPN or ENT stimulated increases in the fractional rate of protein synthesis (ks) in skeletal muscle. Alcohol prevented the increase in ks when refeeding occurred intragastrically (TPN or ENT) (P < 0.001) but not intravenously (TPN). Upon intragastric refeeding, alcohol inhibited the increase in both eukaryotic initiation factor 4E-binding protein-1 (4E-BP1) and p70 S6 kinase (p70S6K) phosphorylation in plantaris but caused only partial inhibition in soleus muscle (ENT only). When rats were refed intravenously, alcohol had no effect on the increased 4E-BP1 or p70S6K phosphorylation in either muscle. Plasma insulin levels were augmented by alcohol. Alcohol-related changes in plasma amino acid concentrations were similar irrespective of the route of feeding, whereas IGF-I levels showed differential changes. This is the first study to demonstrate that acute alcohol ingestion impedes the starved-to-fed response in skeletal muscle.

fasting; myopathy; protein synthesis; ethanol; feeding


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[Abstract] [Full Text] [PDF]


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