AJP - Endo AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 284: E778-E787, 2003. First published December 27, 2002; doi:10.1152/ajpendo.00128.2002
0193-1849/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/4/E778    most recent
00128.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dobbins, R. L.
Right arrow Articles by McGarry, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dobbins, R. L.
Right arrow Articles by McGarry, J. D.
Vol. 284, Issue 4, E778-E787, April 2003

Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion

Robert L. Dobbins1, Lidia S. Szczepaniak1, Weiguo Zhang1, and J. Denis McGarry1,2

Departments of 1 Internal Medicine and 2 Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9135

To assess the importance of the sympathetic nervous system in regulating body weight during prolonged leptin infusion, we evaluated food intake, body weight, and physical activity in conscious, unrestrained rats. Initial studies illustrated that prolonged intracerebroventricular (ICV) infusion of leptin enhanced substrate oxidation so that adipose tissue lipid stores were completely ablated, and muscle triglyceride and liver glycogen stores were depleted. After neonatal chemical sympathectomy, changes in weight and food intake were compared in groups of sympathectomized (SYM) and control (CON) adult animals during ICV infusion of leptin. CON animals lost 60 ± 9 g over 10 days vs. 25 ± 3 g in the SYM animals when food intake was matched between the two groups. Greater weight loss despite similar energy intake points to an important role of the sympathetic nervous system in stimulating energy expenditure during ICV leptin infusion by increasing the resting metabolic rate, since no differences in physical activity were observed between CON and SYM groups. In conclusion, activation of the SNS by leptin increases energy expenditure by augmenting the resting metabolic rate.

lipid oxidation; sympathetic nervous system; intracerebroventricular


This article has been cited by other articles:


Home page
 Evid Based Complement Alternat MedHome page
S.-W. Lee, J.-H. Yoo, S.-K. Lee, K.-S. Keum, D.-G. Ryu, and K.-B. Kwon
Taeyeumjoweetang Affects Body Weight and Obesity-related Genes in Mice
Evid. Based Complement. Altern. Med., September 1, 2009; 6(suppl_1): 81 - 86.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Wang, E. Bomberg, C. Billington, A. Levine, and C. M. Kotz
Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R992 - R1002.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Y.-H. Yu and H. N. Ginsberg
Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin-Resistant Adipose Tissue
Circ. Res., May 27, 2005; 96(10): 1042 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. L. Haltiner, T. D. Mitchell, and R. B. S. Harris
Leptin action is modified by an interaction between dietary fat content and ambient temperature
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1250 - R1255.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online