AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 284: E583-E588, 2003. First published November 26, 2002; doi:10.1152/ajpendo.00350.2002
0193-1849/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/3/E583    most recent
00350.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (57)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gomori, A.
Right arrow Articles by Kanatani, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gomori, A.
Right arrow Articles by Kanatani, A.
Vol. 284, Issue 3, E583-E588, March 2003

Chronic intracerebroventricular infusion of MCH causes obesity in mice

Akira Gomori, Akane Ishihara, Masahiko Ito, Satoshi Mashiko, Hiroko Matsushita, Mariko Yumoto, Makoto Ito, Takeshi Tanaka, Shigeru Tokita, Minoru Moriya, Hisashi Iwaasa, and Akio Kanatani

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Okubo 3, Tsukuba 300 - 2611, Japan

Melanin-concentrating hormone (MCH) is a cyclic amino acid neuropeptide localized in the lateral hypothalamus. Although MCH is thought to be an important regulator of feeding behavior, the involvement of this peptide in body weight control has been unclear. To examine the role of MCH in the development of obesity, we assessed the effect of chronic intracerebroventricular infusion of MCH in C57BL/6J mice that were fed with regular or moderately high-fat (MHF) diets. Intracerebroventricular infusion of MCH (10 µg/day for 14 days) caused a slight but significant increase in body weight in mice maintained on the regular diet. In the MHF diet-fed mice, MCH more clearly increased the body weight accompanied by a sustained hyperphagia and significant increase in fat and liver weights. Plasma glucose, insulin, and leptin levels were also increased in the MCH-treated mice fed the MHF diet. These results suggest that chronic stimulation of the brain MCH system causes obesity in mice and imply that MCH may have a major role in energy homeostasis.

melanin-concentrating hormone; food intake; body weight; fat weight


This article has been cited by other articles:


Home page
 J EndocrinolHome page
M. Ito, A. Gomori, J. Suzuki, S. Tsujioka, M. Sasaki, M. Matsuda, M. A Bednarek, M. Ito, A. Ishihara, H. Iwaasa, et al.
Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice
J. Endocrinol., August 1, 2008; 198(2): 309 - 315.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Y. Jeon, R. L. Bradley, E. G. Kokkotou, F. E. Marino, X. Wang, P. Pissios, and E. Maratos-Flier
MCH-/- Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance
Diabetes, February 1, 2006; 55(2): 428 - 434.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Alon and J. M. Friedman
Late-Onset Leanness in Mice with Targeted Ablation of Melanin Concentrating Hormone Neurons
J. Neurosci., January 11, 2006; 26(2): 389 - 397.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
A.-K. Wermter, K. Reichwald, T. Buch, F. Geller, C. Platzer, K. Huse, C. Hess, H. Remschmidt, T. Gudermann, G. Preibisch, et al.
Mutation analysis of the MCHR1 gene in human obesity
Eur. J. Endocrinol., June 1, 2005; 152(6): 851 - 862.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. G. Challis, A. P. Coll, G. S. H. Yeo, S. B. Pinnock, S. L. Dickson, R. R. Thresher, J. Dixon, D. Zahn, J. J. Rochford, A. White, et al.
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36
PNAS, March 30, 2004; 101(13): 4695 - 4700.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Ito, A. Gomori, A. Ishihara, Z. Oda, S. Mashiko, H. Matsushita, M. Yumoto, M. Ito, H. Sano, S. Tokita, et al.
Characterization of MCH-mediated obesity in mice
Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E940 - E945.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online