AJP - Endo Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 284: E499-E504, 2003. First published November 5, 2002; doi:10.1152/ajpendo.00156.2002
0193-1849/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/3/E499    most recent
00156.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carlsson, P.-O.
Right arrow Articles by Palm, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carlsson, P.-O.
Right arrow Articles by Palm, F.
Vol. 284, Issue 3, E499-E504, March 2003

pH is decreased in transplanted rat pancreatic islets

Per-Ola Carlsson1, Astrid Nordin1, and Fredrik Palm1,2

Departments of 1 Medical Cell Biology and 2 Diagnostic Radiology, Uppsala University, SE-751 23 Uppsala, Sweden

Recent studies of transplanted pancreatic islets have indicated incomplete revascularization. We investigated the pH, in relation to oxygen tension (PO2), in endogenous islets and islets syngeneically transplanted to the renal subcapsular site of nondiabetic and streptozotocin-diabetic recipients. Tissue pH and PO2 were measured using microelectrodes. In the endogenous islets, tissue pH was similar to that in arterial blood. In the transplanted islets, tissue pH was 0.11-0.15 pH units lower. No differences in islet graft pH were seen between nondiabetic and diabetic animals, and none if the islet grafts were investigated 1 day or 1 mo posttransplantation. The PO2 in the endogenous islets was ~35 mmHg. Transplanted islets had a markedly lower tissue PO2 both 1 day and 1 mo after transplantation. A negative correlation between the tissue PO2 and the hydrogen ion concentration was seen in the 1-mo-old islet transplants in diabetic animals. In conclusion, decreased PO2 in transplanted islets is associated with a decreased tissue pH, suggesting a shift toward more anaerobic glucose metabolism after transplantation.

oxygen tension; revascularization; islet graft; metabolism; engraftment


This article has been cited by other articles:


Home page
 DiabetesHome page
J. Olerud, M. Johansson, J. Lawler, N. Welsh, and P.-O. Carlsson
Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
Diabetes, July 1, 2008; 57(7): 1870 - 1877.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Lau, G. Mattsson, C. Carlsson, D. Nyqvist, M. Kohler, P.-O. Berggren, L. Jansson, and P.-O. Carlsson
Implantation Site-Dependent Dysfunction of Transplanted Pancreatic Islets
Diabetes, June 1, 2007; 56(6): 1544 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
G. Mattsson, L. Jansson, A. Nordin, A. Andersson, and P.-O. Carlsson
Evidence of Functional Impairment of Syngeneically Transplanted Mouse Pancreatic Islets Retrieved from the Liver
Diabetes, April 1, 2004; 53(4): 948 - 954.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online