AJP - Endo Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 284: E443-E448, 2003. First published October 8, 2002; doi:10.1152/ajpendo.00358.2002
0193-1849/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/E443    most recent
00358.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lihn, A. S.
Right arrow Articles by Schmitz, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lihn, A. S.
Right arrow Articles by Schmitz, O.
Vol. 284, Issue 2, E443-E448, February 2003

Adiponectin expression in adipose tissue is reduced in first-degree relatives of type 2 diabetic patients

A. S. Lihn1, T. Østergård2, B. Nyholm2, S. B. Pedersen1, B. Richelsen1, and O. Schmitz2

1 Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital and Faculty of Health Sciences, Aarhus University and 2 Department of Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus University Hospital, DK-8000 Aarhus C, Denmark

Adiponectin is suggested to be an important mediator of insulin resistance. Therefore, we investigated the association between adiponectin and insulin sensitivity in 22 healthy first-degree relatives (FDR) to type 2 diabetic patients and 13 matched control subjects. Subcutaneous adipose tissue biopsies were taken before and after a hyperinsulinemic euglycemic clamp. FDR subjects were insulin resistant, as indicated by a reduced M value (4.44 vs. 6.09 mg · kg-1 · min-1, P < 0.05). Adiponectin mRNA expression was 45% lower in adipose tissue from FDR compared with controls (P < 0.01), whereas serum adiponectin was similar in the two groups (6.4 vs. 6.6 µg/ml, not significant). Insulin infusion reduced circulating levels of adiponectin moderately (11-13%) but significantly in both groups (P < 0.05). In the control group, adiponectin mRNA levels were negatively correlated with fasting insulin (P < 0.05) and positively correlated with insulin sensitivity (P < 0.05). In contrast, these associations were not found in the FDR group. In conclusion, FDR have reduced adiponectin mRNA in subcutaneous adipose tissue but normal levels of circulating adiponectin. Adiponectin mRNA levels are positively correlated with insulin sensitivity in control subjects but not in FDR. These findings indicate dysregulation of adiponectin gene expression in FDR.

30-kilodalton adipose complement-related protein; gene expression; genetic predisposition to disease; insulin; first-degree relatives


This article has been cited by other articles:


Home page
 DiabetesHome page
E. Chevillotte, M. Giralt, B. Miroux, D. Ricquier, and F. Villarroya
Uncoupling Protein-2 Controls Adiponectin Gene Expression in Adipose Tissue Through the Modulation of Reactive Oxygen Species Production
Diabetes, April 1, 2007; 56(4): 1042 - 1050.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
I. Kowalska, M. Straczkowski, A. Nikolajuk, A. Krukowska, I. Kinalska, and M. Gorska
Plasma adiponectin concentration and tumor necrosis factor-{alpha} system activity in lean non-diabetic offspring of type 2 diabetic subjects
Eur. J. Endocrinol., February 1, 2006; 154(2): 319 - 324.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. S. Lihn, B. Richelsen, S. B. Pedersen, S. B. Haugaard, G. S. Rathje, S. Madsbad, and O. Andersen
Increased expression of TNF-{alpha}, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1072 - E1080.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. Pellme, U. Smith, T. Funahashi, Y. Matsuzawa, H. Brekke, O. Wiklund, M.-R. Taskinen, and P.-A. Jansson
Circulating Adiponectin Levels Are Reduced in Nonobese but Insulin-Resistant First-Degree Relatives of Type 2 Diabetic Patients
Diabetes, May 1, 2003; 52(5): 1182 - 1186.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online