AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 284: E340-E350, 2003. First published October 22, 2002; doi:10.1152/ajpendo.00253.2002
0193-1849/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/E340    most recent
00253.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spangenburg, E. E.
Right arrow Articles by Booth, F. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spangenburg, E. E.
Right arrow Articles by Booth, F. W.
Vol. 284, Issue 2, E340-E350, February 2003

Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent

Espen E. Spangenburg, Tsghe Abraha, Tom E. Childs, J. Scott Pattison, and Frank W. Booth

Departments of Biomedical Sciences and of Physiology, and the Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri 65211

The purpose of the current study was to examine IGFBP-3, -4, and -5 mRNA and protein expression levels as a function of muscle type, age, and regrowth from an immobilization-induced atrophy in Fischer 344 × Brown Norway rats. IGFBP-3 mRNA expression in the 4-mo-old animals was significantly higher in the red and white portions of the gastrocnemius muscle compared with the soleus muscle. However, there were no significant differences in IGFBP-3 mRNA expression among any of the muscle groups in the 30-mo-old animals. There were no significant differences in IGFBP-5 mRNA expression in any of the muscle groups, whereas in the 30-mo-old animals there was significantly less IGFBP-5 mRNA expression in the white gastrocnemius compared with the red gastrocnemius muscles. Although IGFBP-3 and -5 proteins were detected in the type I soleus muscle with Western blot analyses, no detection was observed in the type II red and white portions of the gastrocnemius muscle. Aging from adult (18 mo) to old animals (30 mo) was associated with decreases in IGFBP-3 mRNA and protein and IGFBP-5 protein only in the soleus muscle. After 10 days of recovery from 10 days of hindlimb immobilization, IGFBP-3 mRNA and protein increased in soleus muscles from young (4-mo) rats; however, only IGFBP-3 protein increased in the old (30-mo) rats. Whereas there were no changes in IGFBP-5 mRNA expression during recovery, IGFBP-5 protein in the 10-day-recovery soleus muscle did increase in the young, but not in the old, rats. Because one of the functions of IGFBPs is to modulate IGF-I action on muscle size and phenotype, it is hypothesized that IGFBP-3 and -5 proteins may have potential modulatory roles in type I fiber-dominated muscles, aging, and regrowth from atrophy.

insulin-like growth factor-binding protein; insulin-like growth factor I; growth; hypertrophy; fiber type


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
R. A. Dennis, B. Przybyla, C. Gurley, P. M. Kortebein, P. Simpson, D. H. Sullivan, and C. A. Peterson
Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise
Physiol Genomics, February 19, 2008; 32(3): 393 - 400.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. D. Hand, M. C. Kostek, R. E. Ferrell, M. J. Delmonico, L. W. Douglass, S. M. Roth, J. M. Hagberg, and B. F. Hurley
Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults
J Appl Physiol, November 1, 2007; 103(5): 1678 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Devaney, E. P. Hoffman, H. Gordish-Dressman, A. Kearns, E. Zambraski, and P. M. Clarkson
IGF-II gene region polymorphisms related to exertional muscle damage
J Appl Physiol, May 1, 2007; 102(5): 1815 - 1823.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
A M Solomon and P M G Bouloux
Modifying muscle mass - the endocrine perspective.
J. Endocrinol., November 1, 2006; 191(2): 349 - 360.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. E. Spangenburg, D. A. Brown, M. S. Johnson, and R. L. Moore
Exercise increases SOCS-3 expression in rat skeletal muscle: potential relationship to IL-6 expression
J. Physiol., May 1, 2006; 572(3): 839 - 848.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. H. Lang, B. J. Krawiec, D. Huber, J. M. McCoy, and R. A. Frost
Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R963 - R972.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. S. Pattison, L. C. Folk, R. W. Madsen, T. E. Childs, and F. W. Booth
Transcriptional profiling identifies extensive downregulation of extracellular matrix gene expression in sarcopenic rat soleus muscle
Physiol Genomics, September 29, 2003; 15(1): 34 - 43.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online