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Am J Physiol Endocrinol Metab 284: E90-E95, 2003. First published August 20, 2002; doi:10.1152/ajpendo.00333.2002
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Vol. 284, Issue 1, E90-E95, January 2003

Influence of oral contraceptive use on endothelial t-PA release in healthy premenopausal women

Greta L. Hoetzer1, Brian L. Stauffer1,2, Jared J. Greiner1, Yoli Casas1, Derek T. Smith1, and Christopher A. DeSouza1,3

1 Integrative Vascular Biology Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309; and Divisions of 2 Cardiology and 3 Geriatrics, Department of Medicine, University of Colorado, Health Sciences Center, Denver, Colorado 80262

We determined the influence of oral contraceptives (OC) on the capacity of the endothelium to release tissue-type plasminogen activator (t-PA). Twenty-three healthy premenopausal women were studied: 12 nonusers and 11 users of OC. Net endothelial release rates of t-PA were calculated as the product of the arteriovenous concentration gradient and forearm plasma flow in response to intra-arterial bradykinin (BK: 12.5-50 ng · 100 ml tissue-1 · min-1) and sodium nitroprusside (SNP: 1.0-4.0 µg · 100 ml tissue-1 · min-1). Net release of t-PA antigen and increment in t-PA activity across the forearm to BK increased (P < 0.01) in a dose-dependent fashion and to similar extents in the nonusers and users of OC. At the highest BK dose, net release of t-PA antigen was 64.5 ± 8.2 and 66.2 ± 15.4 ng · 100 ml tissue-1 · min-1 in the nonusers and users of OC, whereas the net increment in t-PA activity was 18.6 ± 3.0 and 16.0 ± 2.0 IU · 100 ml tissue-1 · min-1, respectively. There was no effect of SNP on t-PA release in either group. These results indicate that endothelial t-PA release is not altered in premenopausal women who use oral contraception.

fibrinolysis; endothelium; tissue-type plasminogen activator; bradykinin; contraceptives


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