AJP - Endo Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 283: E1173-E1177, 2002. First published July 30, 2002; doi:10.1152/ajpendo.00233.2002
0193-1849/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/6/E1173    most recent
00233.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (39)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dakin, C. L.
Right arrow Articles by Bloom, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dakin, C. L.
Right arrow Articles by Bloom, S. R.
Vol. 283, Issue 6, E1173-E1177, December 2002

Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats

Catherine L. Dakin, Caroline J. Small, Adrian J. Park, Asha Seth, Mohammad A. Ghatei, and Stephen R. Bloom

Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom

Oxyntomodulin (OXM) is a product of proglucagon processing in the intestine and the central nervous system. We reported that intracerebroventricular (ICV) and intranuclear administration of OXM caused an inhibition of food intake in rats (Dakin CL, Gunn I, Small CJ, Edwards CM, Hay DL, Smith DM, Ghatei MA, and Bloom SR. Endocrinology 142: 4244-4250, 2001). In this study, we investigated the effect of twice-daily ICV administration of OXM, 1 nmol, for 7 days. A pair-fed control was included. These animals were restricted to the food intake of the OXM group but injected twice daily with saline. OXM-treated animals gained significantly less weight than either control group (day 8: OXM, 12.2 ± 1.9 g vs. pair fed, 21.0 ± 2.1 g; P < 0.005). OXM treatment caused a reduction in epididymal white adipose tissue (OXM, 1.13 ± 0.03 g vs. pair fed, 1.29 ± 0.04 g; P < 0.05) and interscapular brown adipose tissue (OXM, 0.15 ± 0.01 g vs. pair fed, 0.18 ± 0.01 g; P < 0.05) and increased core temperature compared with saline control, suggestive of enhanced energy expenditure. The food restriction-induced suppression in plasma TSH, seen in the pair-fed group, was prevented by OXM, potentially via increased release of hypothalamic TRH. In summary, ICV OXM causes reduced body weight gain and body adiposity following chronic administration.

glucagon-like peptide-1; energy expenditure; core temperature


This article has been cited by other articles:


Home page
 Diabetes CareHome page
O. B. Chaudhri, K. Wynne, and S. R. Bloom
Can Gut Hormones Control Appetite and Prevent Obesity?
Diabetes Care, February 1, 2008; 31(Supplement_2): S284 - S289.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. L. Sowden, D. J. Drucker, D. Weinshenker, and S. J. Swoap
Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R962 - R970.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
G. G. Gosman, H. I. Katcher, and R. S. Legro
Obesity and the role of gut and adipose hormones in female reproduction
Hum. Reprod. Update, September 1, 2006; 12(5): 585 - 601.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
O. Chaudhri, C. Small, and S. Bloom
Gastrointestinal hormones regulating appetite
Phil Trans R Soc B, July 29, 2006; 361(1471): 1187 - 1209.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online