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Am J Physiol Endocrinol Metab 283: E929-E936, 2002. First published June 25, 2002; doi:10.1152/ajpendo.00539.2001
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Vol. 283, Issue 5, E929-E936, November 2002

Effect of training on the GH/IGF-I axis during exercise in middle-aged men: relationship to glucose homeostasis

Jérôme Manetta1, Jean Frederic Brun1, Laurent Maimoun2, Albert Callis3, Christian Préfaut1, and Jacques Mercier1

Metabolic Unit, 1 Service Central de Physiologie Clinique: Centre d'Exploration et de Réadaptation des Anomalies Métaboliques et Musculaires, and 2 Service de Médecine Nucléaire, hôpital Lapeyronie, 34295 Montpellier; and 3 Service de Biochimie B, Centre Hospitalier Universitaire, Saint Eloi, 34295 Montpellier, France

The aim of this study was to compare circulating levels of growth hormone (GH), IGF-I, and IGF-binding protein (IGFBP)-1 and IGFBP-3 in response to a long-duration endurance exercise in trained vs. sedentary middle-aged males and to determine whether a relationship with glucose homeostasis exists. Seven trained men (Tr) were compared with seven age-matched sedentary men (Sed) during two trials of 60 min of cycling exercise performed below (-VT) and above (+VT) the ventilatory threshold. Insulin sensitivity (SI) was higher in Tr than in Sed (P < 0.001). Basal GH, IGF-I, and IGFBP-1 and -3 were higher in Tr (P < 0.05). During +VT, Tr had a threefold higher GH response, whereas their blood glucose level was better maintained (P < 0.05). Basal IGFBP-1 was correlated with SI (P < 0.01). These data indicate that endurance training in middle-aged men increased the activity of the GH/IGF-I system and improved glucoregulation both at rest and during high-intensity endurance exercise.

endurance training; insulin sensitivity; insulin-like growth factor I; insulin-like growth factor-binding protein-1 and -3; middle age


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