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Am J Physiol Endocrinol Metab 282: E370-E375, 2002. First published October 30, 2001; doi:10.1152/ajpendo.00296.2001
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Vol. 282, Issue 2, E370-E375, February 2002

Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus

Yuval Heled1, Yair Shapiro1, Yoav Shani1, Dani S. Moran1, Lea Langzam2, Liora Braiman2, Sanford R. Sampson2, and Joseph Meyerovitch3

1 Heller Institute of Medical Research and 3 Pediatric Division, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv 52621; and 2 Faculty of Life Science, Gonda-Goldschmied Center, Bar-Ilan University, Ramat Gan 529, Israel

We hypothesized that exercise training might prevent diabetes mellitus in Psammomys obesus. Animals were assigned to three groups: high-energy diet (CH), high-energy diet and exercise (EH), and low-energy diet (CL). The EH group ran on a treadmill 5 days/wk, twice a day. After 4 wk, 93% of the CH group were diabetic compared with only 20% of the EH group. There was no difference in weight gain among the groups. Both EH and CH groups were hyperinsulinemic. Epididymal fat (% of body weight) was higher in the CH group than in either the EH and or the CL group. Protein kinase C (PKC)-delta activity and serine phosphorylation were higher in the EH group. No differences were found in tyrosine phosphorylation of the insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase among the groups. We demonstrate for the first time that exercise training effectively prevents the progression of diabetes mellitus type 2 in Psammomys obesus. PKC-delta may be involved in the adaptive effects of exercise in skeletal muscles that lead to the prevention of type 2 diabetes mellitus.

type 2 diabetes mellitus; physical exercise; Psammomys obesus; protein kinase C-delta


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