AJP - Endocrinology and Metabolism, Vol 265, Issue 3 E380-E391, Copyright © 1993 by American Physiological Society

ARTICLES

Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration

J. A. Romijn, E. F. Coyle, L. S. Sidossis, A. Gastaldelli, J. F. Horowitz, E. Endert and R. R. Wolfe
Metabolism Unit, Shriners Burns Institute, University of Texas Medical Branch, Galveston 77550.

Stable isotope tracers and indirect calorimetry were used to evaluate the regulation of endogenous fat and glucose metabolism in relation to exercise intensity and duration. Five trained subjects were studied during exercise intensities of 25, 65, and 85% of maximal oxygen consumption (VO2max). Plasma glucose tissue uptake and muscle glycogen oxidation increased in relation to exercise intensity. In contrast, peripheral lipolysis was stimulated maximally at the lowest exercise intensity, and fatty acid release into plasma decreased with increasing exercise intensity. Muscle triglyceride lipolysis was stimulated only at higher intensities. During 2 h of exercise at 65% VO2max plasma-derived substrate oxidation progressively increased over time, whereas muscle glycogen and triglyceride oxidation decreased. In recovery from high-intensity exercise, although the rate of lipolysis immediately decreased, the rate of release of fatty acids into plasma increased, indicating release of fatty acids from previously hydrolyzed triglycerides. We conclude that, whereas carbohydrate availability is regulated directly in relation to exercise intensity, the regulation of lipid metabolism seems to be more complex.

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				B. Morio, J.-F. Hocquette, C. Montaurier, Y. Boirie, C. Bouteloup-Demange, C. McCormack, N. Fellmann, B. Beaufrere, and P. Ritz Muscle fatty acid oxidative capacity is a determinant of whole body fat oxidation in elderly people Am J Physiol Endocrinol Metab, January 1, 2001; 280(1): E143 - E149. [Abstract] [Full Text] [PDF]

				J. F. Horowitz and S. Klein Oxidation of nonplasma fatty acids during exercise is increased in women with abdominal obesity J Appl Physiol, December 1, 2000; 89(6): 2276 - 2282. [Abstract] [Full Text] [PDF]

				J. H. Goedecke, A. S. C. Gibson, L. Grobler, M. Collins, T. D. Noakes, and E. V. Lambert Determinants of the variability in respiratory exchange ratio at rest and during exercise in trained athletes Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1325 - E1334. [Abstract] [Full Text] [PDF]

				B. D. Roy, H. J. Green, and M. Burnett Prolonged exercise after diuretic-induced hypohydration: effects on substrate turnover and oxidation Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1383 - E1390. [Abstract] [Full Text] [PDF]

				G. K. McConell, B. J. Canny, M. C. Daddo, M. J. Nance, and R. J. Snow Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise J Appl Physiol, November 1, 2000; 89(5): 1690 - 1698. [Abstract] [Full Text] [PDF]

				Z. Guo, B. Burguera, and M. D. Jensen Kinetics of intramuscular triglyceride fatty acids in exercising humans J Appl Physiol, November 1, 2000; 89(5): 2057 - 2064. [Abstract] [Full Text] [PDF]

				D. Malkova, R. D. Evans, K. N. Frayn, S. M. Humphreys, P. R. M. Jones, and A. E. Hardman Prior exercise and postprandial substrate extraction across the human leg Am J Physiol Endocrinol Metab, November 1, 2000; 279(5): E1020 - E1028. [Abstract] [Full Text] [PDF]

				C. J. Pritzlaff, L. Wideman, J. Blumer, M. Jensen, R. D. Abbott, G. A. Gaesser, J. D. Veldhuis, and A. Weltman Catecholamine release, growth hormone secretion, and energy expenditure during exercise vs. recovery in men J Appl Physiol, September 1, 2000; 89(3): 937 - 946. [Abstract] [Full Text] [PDF]

				R. J. Geor, K. W. Hinchcliff, and R. A. Sams beta -Adrenergic blockade augments glucose utilization in horses during graded exercise J Appl Physiol, September 1, 2000; 89(3): 1086 - 1098. [Abstract] [Full Text] [PDF]

				E. F Coyle Physical activity as a metabolic stressor Am. J. Clinical Nutrition, August 1, 2000; 72(2): 512S - 520. [Abstract] [Full Text] [PDF]

				J. F Horowitz and S. Klein Lipid metabolism during endurance exercise Am. J. Clinical Nutrition, August 1, 2000; 72(2): 558S - 563. [Abstract] [Full Text] [PDF]