AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab (February 14, 2006). doi:10.1152/ajpendo.00652.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
291/1/E1    most recent
00652.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greenberg, C. C
Right arrow Articles by Brady, M. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greenberg, C. C
Right arrow Articles by Brady, M. J
Submitted on December 28, 2005
Accepted on February 9, 2006

Glycogen Branches Out: New Perspectives on the Role of Glycogen Metabolism in the Integration of Metabolic Pathways

Cynthia C Greenberg1, Michael J Jurczak1, Arpad M Danos1, and Matthew J Brady1*

1 Medicine, University of Chicago, Chicago, IL, USA

* To whom correspondence should be addressed. E-mail: mbrady{at}medicine.bsd.uchicago.edu.

Glycogen is the storage form of carbohydrate for virtually every organism from yeast to primates. Most mammalian tissues store glucose as glycogen with the major depots located in muscle and liver. The French physiologist Claude Bernard first identified a starch-like substance in liver and muscle and coined the term "glycogen" or "sugar former" in the 1850s. During the 150 years since its identification, researchers in the field of glycogen metabolism have made numerous discoveries that are now recognized as significant milestones in biochemistry and cell signaling. Even so, more questions remain, and studies continue to demonstrate the complexity of the regulation of glycogen metabolism. Under classical definitions, the functions of glycogen seem clear: muscle glycogen is degraded to generate ATP during increased energy demand, whereas hepatic glycogen is broken down for release of glucose to the bloodstream to supply other tissues. However, recent findings demonstrate that the roles of glycogen in energy sensing, integration of metabolic pathways, and coordination of cellular responses to hormonal stimuli are far more complex.




This article has been cited by other articles:


Home page
 Stem CellsHome page
S. Agarwal, K. L. Holton, and R. Lanza
Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells
Stem Cells, May 1, 2008; 26(5): 1117 - 1127.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. A. Omar, H. Fraser, and A. S. Clanachan
Ischemia-induced activation of AMPK does not increase glucose uptake in glycogen-replete isolated working rat hearts
Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1266 - H1273.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. P. Warne, M. T. Foster, H. F. Horneman, N. C. Pecoraro, H. K. de Jong, A. B. Ginsberg, S. F. Akana, and M. F. Dallman
The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats
Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E190 - E200.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. P. Warne, M. T. Foster, H. F. Horneman, N. C. Pecoraro, A. B. Ginsberg, S. F. Akana, and M. F. Dallman
Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats
J. Physiol., September 1, 2007; 583(2): 455 - 467.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.