Submitted on October 5, 2007
Accepted on November 7, 2007
Insulin-Like Growth Factor Binding Proteins and Bone Metabolism
Cheryl Conover1*
1 Endocrine Research Unit, Mayo Clinic, Rochester,, Minnesota, United States
* To whom correspondence should be addressed. E-mail: conover{at}mayo.edu.
Insulin-like growth factor binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood since IGFBPs can have both enhancing and inhibiting effects on IGF action, depending on context and post-translational modifications, as well as IGF-independent effects. This review focuses on recent findings from cell culture, rodent models and clinical studies concerning local IGFBP-2, IGFBP-4, and IGFBP-5 action in bone.
