AJP - Endo Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 QUICK SEARCH:   [advanced]


     


Am J Physiol Endocrinol Metab (December 4, 2007). doi:10.1152/ajpendo.00642.2007
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
294/2/E380    most recent
00642.2007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, K. M. S.
Right arrow Articles by Cherrington, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, K. M. S.
Right arrow Articles by Cherrington, A. D.
Submitted on October 3, 2007
Accepted on December 4, 2007

Intraportally Delivered GLP-1, in the Presence of Hyperglycemia Induced via Peripheral Glucose Infusion, Does Not Change Whole Body Glucose Utilization

Kathryn Mercedes Stettler Johnson1*, Dale S Edgerton1, Tiffany D Rodewald1, Melanie Scott1, Ben Farmer1, Doss W Neal1, and Alan D. Cherrington1

1 Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States

* To whom correspondence should be addressed. E-mail: kathryn.johnson{at}vanderbilt.edu.

After a meal, glucagon-like peptide-1 (GLP-1) and glucose levels are significantly greater in the hepatic portal vein than in the artery. We have previously reported that in the presence of intraportal glucose delivery, a physiological increase of GLP-1 in the hepatic portal vein increases nonhepatic glucose uptake via a mechanism independent of changes in pancreatic hormone secretion. The aim of the current study was to determine if intraportal glucose delivery is required to observe this effect. Experiments consisted of a 40-min basal period, followed by a 240-min experimental period, during which conscious 42-h fasted dogs received glucose peripherally to maintain arterial plasma glucose levels at ~160 mg/dl. In addition, either saline (SAL, n=6) or GLP-1 (1 pmol/kg/min; GLP-1, n=6) was administered intraportally during the experimental period. As in the previous study, the presence of GLP-1 did not alter pancreatic hormone levels; however in the current study the presence of an intraportal GLP-1 infusion did not result in an increase in whole body glucose utilization. This is despite the fact that arterial and hepatic portal vein GLP-1 levels were maintained at the same level as the previous study. Therefore, a physiological elevation of GLP-1 in the hepatic portal vein does not increase whole body glucose uptake when hyperglycemia is induced by peripheral glucose infusion. This indicates that that a physiological increase in GLP-1 augments glucose utilization only when GLP-1 and glucose gradients conditions mimic the postprandial state.




This article has been cited by other articles:


Home page
DiabetesHome page
D. Zheng, V. Ionut, V. Mooradian, D. Stefanovski, and R. N. Bergman
Exenatide Sensitizes Insulin-Mediated Whole-Body Glucose Disposal and Promotes Uptake of Exogenous Glucose by the Liver
Diabetes, February 1, 2009; 58(2): 352 - 359.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
D. S. Edgerton, K. M.S. Johnson, D. W. Neal, M. Scott, C. H. Hobbs, X. Zhang, A. Duttaroy, and A. D. Cherrington
Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog
Diabetes, January 1, 2009; 58(1): 243 - 249.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
V. Ionut, D. Zheng, D. Stefanovski, and R. N. Bergman
Exenatide can reduce glucose independent of islet hormones or gastric emptying
Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E269 - E277.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2007 by the American Physiological Society.