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Am J Physiol Endocrinol Metab (March 1, 2005). doi:10.1152/ajpendo.00603.2004
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Submitted on December 20, 2004
Accepted on February 28, 2005

Repeated light-dark shifts speed up body weight gain in male F344 rats

Ling-Ling Tsai1*, Yu-Che Tsai1, Kai Hwang1, Yu-Wen Huang2, and Jeh-En Tzeng3

1 Department of Psychology, National Chung-Cheng University, Chia-yi, Taiwan
2 Department of Laboratory Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia-yi, Taiwan
3 Department of Pathology, Buddhist Dalin Tzu Chi General Hospital, Chia-yi, Taiwan

* To whom correspondence should be addressed. E-mail: psyllt{at}ccu.edu.tw.

This study is aimed at verifying the causal relationship of chronic circadian desynchronization and changes in body weight control. Eight male albino F344 rats aged between 12-15 weeks were subjected to twice-weekly 12-h shifts of the daily light-dark (LD) cycle for 13 weeks (3 months). Continuous circadian phase shifts consisting of intermittent phase delay and advance and reduced circadian amplitudes were consistently displayed in all the five experimental rats implanted intraperitoneally with heart rate, body temperature, and activity transponders. The experimental rat maintained a greater body weight during LD shifts and even after 10 days of recovery than that of the age-matched control rat, which was maintained in a regular LD cycle. Body weight gain was greater in the first two months of LD shifts in the experimental rat than in the control rat. Relative to the baseline, food intake and activity percentages were increased and reduced, respectively, for the experimental rats. Features of these results, such as increased body weight gain and food intake, and reduced activity, suggest a causal relationship of chronic circadian desynchronization and changes in body weight control in male albino F344 rats.




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