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1 Gruss MRRC , Albert Einstein College of Medicine, Bronx, New York, United States; Department of Medicine, Endocrinology Division, Albert Einstein College of Medicine, Bronx, New York, United States
2 Department of Medicine, Endocrinology Division, Albert Einstein College of Medicine, Bronx, New York, United States
* To whom correspondence should be addressed. E-mail: jhhwang{at}aecom.yu.edu.
Recent studies have indicated that the mass/content of intramyocellular lipid (IMCL), intrahepatic triglyceride (IHTG), visceral fat (VF) and even deep abdominal subcutaneous fat (SF) may all be correlated with insulin resistance. Since simultaneous measurements of these parameters have not been reported, the relative strength of their associations with insulin action is not known. Therefore, the goals of this study were: 1) to simultaneously measure IMCL, IHTG, VF and abdominal SF in the same non-diabetic individuals using noninvasive 1H magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI), and 2) to examine how these fat stores are correlated with systemic insulin sensitivity as measured by whole body glucose disposal (Rd) during euglycemic hyperinsulinemic clamp studies. Positive correlations were observed among IMCL, IHTG and VF. There were significant inverse correlations between whole body glucose disposal and both IMCL and VF. Notably, there was a particularly tight inverse correlation between IHTG and whole body glucose disposal (r = -0.86, p <0.001), consistent with an association between liver fat and peripheral insulin sensitivity. This novel finding suggests that hepatic triglyceride accumulation has important systemic consequences that may adversely affect insulin sensitivity in other tissues.
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