| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Gruss MRRC , Albert Einstein College of Medicine, Bronx, New York, United States; Department of Medicine, Endocrinology Division, Albert Einstein College of Medicine, Bronx, New York, United States
2 Department of Medicine, Endocrinology Division, Albert Einstein College of Medicine, Bronx, New York, United States
* To whom correspondence should be addressed. E-mail: jhhwang{at}aecom.yu.edu.
Recent studies have indicated that the mass/content of intramyocellular lipid (IMCL), intrahepatic triglyceride (IHTG), visceral fat (VF) and even deep abdominal subcutaneous fat (SF) may all be correlated with insulin resistance. Since simultaneous measurements of these parameters have not been reported, the relative strength of their associations with insulin action is not known. Therefore, the goals of this study were: 1) to simultaneously measure IMCL, IHTG, VF and abdominal SF in the same non-diabetic individuals using noninvasive 1H magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI), and 2) to examine how these fat stores are correlated with systemic insulin sensitivity as measured by whole body glucose disposal (Rd) during euglycemic hyperinsulinemic clamp studies. Positive correlations were observed among IMCL, IHTG and VF. There were significant inverse correlations between whole body glucose disposal and both IMCL and VF. Notably, there was a particularly tight inverse correlation between IHTG and whole body glucose disposal (r = -0.86, p <0.001), consistent with an association between liver fat and peripheral insulin sensitivity. This novel finding suggests that hepatic triglyceride accumulation has important systemic consequences that may adversely affect insulin sensitivity in other tissues.
This article has been cited by other articles:
|
|
 |
|
  G. Perseghin Viewpoints on the Way to a Consensus Session: Where does insulin resistance start? The liver Diabetes Care, November 1, 2009; 32(suppl_2): S164 - S167. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Fabbrini, F. Magkos, B. S. Mohammed, T. Pietka, N. A. Abumrad, B. W. Patterson, A. Okunade, and S. Klein Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity PNAS, September 8, 2009; 106(36): 15430 - 15435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Guiu, J.-M. Petit, R. Loffroy, D. Ben Salem, S. Aho, D. Masson, P. Hillon, D. Krause, and J.-P. Cercueil Quantification of Liver Fat Content: Comparison of Triple-Echo Chemical Shift Gradient-Echo Imaging and in Vivo Proton MR Spectroscopy Radiology, January 1, 2009; 250(1): 95 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. K. Sakkas, C. Karatzaferi, E. Zintzaras, C. D. Giannaki, V. Liakopoulos, E. Lavdas, E. Damani, N. Liakos, I. Fezoulidis, Y. Koutedakis, et al. Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1721 - R1729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Anderson and J. Borlak Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis Pharmacol. Rev., September 1, 2008; 60(3): 311 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Deivanayagam, B S. Mohammed, B. E Vitola, G. H Naguib, T. H Keshen, E. P Kirk, and S. Klein Nonalcoholic fatty liver disease is associated with hepatic and skeletal muscle insulin resistance in overweight adolescents Am. J. Clinical Nutrition, August 1, 2008; 88(2): 257 - 262. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
