| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 School of Clinical Medical Sciences (Diabetes), University of Newcastle, Newcastle upon Tyne, United Kingdom
2 Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, United Kingdom
3 Department of Clincal Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
4 Department of Radiology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
5 Institute of Ageing and Health, University of Newcastle, Newcastle upon Tyne, United Kingdom
* To whom correspondence should be addressed. E-mail: Roy.Taylor{at}ncl.ac.uk.
Liver and skeletal muscle triglyceride stores are elevated in type 2 diabetes and correlate with insulin resistance. As postprandial handling of dietary fat may be a critical determinant of tissue triglyceride levels, we quantified postprandial fat storage in normal and type 2 diabetes subjects. Healthy volunteers (n = 8) and diet controlled type 2 diabetes subjects (n = 12) were studied using a novel 13C-magnetic resonance spectroscopy protocol to measure the postprandial increment in liver and skeletal muscle triglyceride following ingestion of 13C-labeled fatty acids given with a standard mixed meal. The postprandial increment in hepatic triglyceride was rapid in both groups (peak increment controls: +7.3 ± 1.5 mmol/l at 6 hours, P = 0.002; peak increment diabetics: +10.8 ± 3.4 mmol/l at 4 hours, P = 0.009). The mean postprandial incremental AUC of hepatic 13C enrichment between the first and second meals (0 and 4 hours) was significantly higher in the diabetes group (6.1 ± 1.4 vs. 1.7 ± 0.6 mmol/l/h; p = 0.019). Postprandial increment in skeletal muscle triglyceride in the control group was small compared to the diabetic group, the mean 24 h postprandial incremental AUC being 0.2 ± 0.3 vs. 1.7 ± 0.4 mmol/l/h (P = 0.009). We conclude that the postprandial uptake of fatty acids by liver and skeletal muscle is increased in type 2 diabetes and may underlie the elevated tissue triglyceride stores and consequent insulin resistance.
This article has been cited by other articles:
|
|
 |
|
  B. Ravikumar, J. Gerrard, C. Dalla Man, M. J. Firbank, A. Lane, P. T. English, C. Cobelli, and R. Taylor Pioglitazone Decreases Fasting and Postprandial Endogenous Glucose Production in Proportion to Decrease in Hepatic Triglyceride Content Diabetes, September 1, 2008; 57(9): 2288 - 2295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kotronen and H. Yki-Jarvinen Fatty Liver: A Novel Component of the Metabolic Syndrome Arterioscler. Thromb. Vasc. Biol., January 1, 2008; 28(1): 27 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P.Y. Koonen, R. L. Jacobs, M. Febbraio, M. E. Young, C.-L. M. Soltys, H. Ong, D. E. Vance, and J. R.B. Dyck Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity Diabetes, December 1, 2007; 56(12): 2863 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Hwang, D. T. Stein, N. Barzilai, M.-H. Cui, J. Tonelli, P. Kishore, and M. Hawkins Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1663 - E1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hodson, A. S.T. Bickerton, S. E. McQuaid, R. Roberts, F. Karpe, K. N. Frayn, and B. A. Fielding The Contribution of Splanchnic Fat to VLDL Triglyceride Is Greater in Insulin-Resistant Than Insulin-Sensitive Men and Women: Studies in the Postprandial State Diabetes, October 1, 2007; 56(10): 2433 - 2441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Knuth and J. F. Horowitz The Elevation of Ingested Lipids within Plasma Chylomicrons Is Prolonged in Men Compared with Women J. Nutr., June 1, 2006; 136(6): 1498 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Kahn The Lipid Accumulation Product Is Better Than BMI for Identifying Diabetes: A population-based comparison Diabetes Care, January 1, 2006; 29(1): 151 - 153. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
