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Am J Physiol Endocrinol Metab (April 1, 2003). doi:10.1152/ajpendo.00557.2002
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Submitted on December 19, 2002
Accepted on March 28, 2003

Effects of dexamethasone and colostrum intake on the somatotropic axis in neonatal calves

STEPHANIE N. SAUTER1, EDGAR ONTSOUKA1, BETTINA ROFFLER1, YOLANDE ZBINDEN1, CHANTAL PHILIPONA1, MICHAEL PFAFFL2, BERNHARD H. BREIER3, JUERG W. BLUM1, and HARALD M. HAMMON1*

1 Division of Animal Nutrition and Physiology, University of Berne, Institute of Animal Genetics, Nutrition and Housing, Faculty of Veterinary Medicine, Berne, Switzerland
2 FML-Weihenstephan, Centre of Life and Food Sciences, Technical University of Munich, Institute of Physiology, Freising-Weihenstephan, Germany
3 Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland, New Zealand

* To whom correspondence should be addressed. E-mail: harald.hammon{at}itz.unibe.ch.

Glucocorticoids and colostrum feeding influence postnatal maturation of the somatotropic axis. We have tested the hypothesis that dexamethasone (DEXA) affects the somatotropic axis in neonatal calves dependent on colostrum intake. Calves were fed either with colostrum or with a milk-based formula (n = 14 per group) and in each feeding group, half of the calves were treated with DEXA (30 µg/[kg body weight x day]). Pre- and postprandial blood samples were taken on days 1, 2, 4, and 5 and liver samples were taken on day 5 of life. DEXA increased insulin-like growth factor (IGF)-I, but decreased growth hormone (GH) and IGF binding protein (IGFBP)-1 and -2 plasma concentrations and increased GH receptor (GHR) mRNA levels in liver. DEXA increased IGF-I mRNA levels only in formula-fed calves and increased hepatic GHR binding capacity, but only in colostrum-fed calves. Colostrum feeding decreased IGFBP-1 and -2 plasma concentrations and hepatic IGFBP-2 and -3 mRNA levels. In conclusion, DEXA and colostrum feeding promoted maturation of the somatotropic axis. DEXA effects partly depended on whether colostrum was fed or not.




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