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Am J Physiol Endocrinol Metab (June 25, 2002). doi:10.1152/ajpendo.00539.2001
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Articles in PresS, published online ahead of print June 25, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00539.2001
Submitted on December 5, 2001
Accepted on June 18, 2002

EFFECT OF TRAINING ON THE GROWTH HORMONE-IGF-I AXIS DURING EXERCISE IN MIDDLE-AGED MEN: RELATIONSHIP WITH GLUCOSE HOMEOSTASIS

Jerome Manetta1*, Jean Frederic Brun1, Laurent Maimoun2, Albert Callis3, Christian Prefaut1, and Jacques Mercier1

1 unite CERAMM, Service de Physiologie Clinique, Hopital Lapeyronie, Montpellier, France
2 medecine nucleaire, Hopital Lapeyronie, Montpellier, France
3 Biochimie B, Hopital Saint Eloi, Montpellier, France

* To whom correspondence should be addressed. E-mail: jerome.manetta{at}free.fr.

The aim of this study was to compare circulating levels of GH, IGF-1, and IGFBP-1 and -3 in response to a long duration endurance exercise at two intensities (i.e. moderate and high) in trained versus sedentary middle-aged males and to determine whether a relationship with glucose homeostasis exists. Seven trained men (Tr) were compared with 7 age-matched sedentary men (Sed) during two trials of 60-min of cycling exercise performed below (-VT) and above (+VT) the ventilatory threshold. Insulin sensitivity (SI) was higher in Tr than in Sed (P< 0.001). Basal GH, IGF-1, and IGFBP-1 and -3 were higher in Tr (P< 0.05). During + VT, Tr had a threefold higher GH response whereas their blood glucose level was better maintained (P< 0.05). Basal IGFBP-1 was correlated to SI (P<0.01). These data indicate that endurance training in middle-aged men increased the activity of the GH/IGF-1 system and improved glucoregulation both at rest and during high intensity endurance exercise.




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