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Am J Physiol Endocrinol Metab (February 25, 2003). doi:10.1152/ajpendo.00513.2002
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Submitted on November 21, 2002
Accepted on February 13, 2003

ACUTE COLD EXPOSURE, LEPTIN AND SOMATOSTATIN ANALOG (OCTREOTIDE) MODULATE THYROID 5'-DEIODINASE ACTIVITY

Patricia Cristina Lisboa1, Karen Jesus Oliveira1, Adriana Cabanelas1, Tania Maria Ortiga-Carvalho1, and Carmen C. Pazos-Moura1*

1 Laboratorio de Endocrinologia Molrcular, Universidade Federal do Rio de Janeiro, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro, RJ, Brazil

* To whom correspondence should be addressed. E-mail: cpazosm{at}biof.ufrj.br.

We investigated the effect of acute cold exposure, leptin and somatostatin analogue, octreotide (OCT) on thyroid type 1 (D1) and 2 (D2) deiodinase activities. Microsomal D1 and D2 activities were measured by the release of 125I from 125I-reverse T3, under different assays conditions. Rats exposed to 4°C (15, 30, 60 and 120 minutes) showed progressive reduction in thyroidal D1 and D2, reaching around 40% at 2h, (p<0,05), despite of increased circulating TSH (p<0,05), associated with the higher thyroid D1 and D2 in hypothyroid rats. Single injection of leptin (8µg/100g BW,sc) induced increased thyroid and liver D1 (p<0.05), but not thyroid D2, activities at 30 and 120 minutes, independently of serum TSH rise, shown only at 2 hours. OCT (1µg/kg BW,sc) increased significantly D1 and D2 activity 24 hours after a single injection, with no changes in serum TSH. Therefore, leptin and somatostatin are potential physiological up-regulators of thyroid deiodinases and their low secretion during acute cold exposure may be potential mechanisms contributing to cold-induced reduction in thyroid deiodinase activity.




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