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Am J Physiol Endocrinol Metab (January 6, 2004). doi:10.1152/ajpendo.00511.2002
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Submitted on November 21, 2002
Accepted on January 2, 2004

Characterization of the portal signal during 24-hour glucose delivery in unrestrained, conscious rats

N. Ogihara1, W. Kawamura1, K. Kasuga1, Y. Hayashi1, H. Arakawa1, and M. Kikuchi1*

1 Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan; Third Department of Internal Medicine, Nihon University, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: m-kikuchi{at}asahi-life.or.jp.

To characterize the "portal signal" during physiological glucose delivery, liver glycogen was measured in unrestrained rats during portal (Po) and peripheral (Pe) constant-rate infusion, with minimal differences in hepatic glucose load (HGL) and portal insulin between the delivery routes. Hepatic blood flows were measured by Doppler flowmetry during open surgery. Changes in hepatic glucose, portal insulin, glucagon, lactate, and FFA concentrations were generally similar in either delivery except for glucagon at 4 h. Hepatic glycogen, however, increased continuously in Po and was higher than Pe at 8 and 24 h, though it decreased to the level of Pe upon the removal of Po at 8 h. There was a near-linear relationship between hepatic glycogen and HGL in either delivery, with the slope being twice as high in Po and the intercepts converging to basal HGL. The hepatic response to Po did not alter upon 80% replacement by Pe. These results suggest that negative arterial-portal glucose gradients increase the rate of hepaticglycogen synthesis against the incremental HGL in an all-or-nothing mode.




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