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Am J Physiol Endocrinol Metab (April 8, 2003). doi:10.1152/ajpendo.00490.2002
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Submitted on November 11, 2002
Accepted on April 2, 2003

INTRAVENOUS ESTROGENS INCREASE INSULIN CLEARANCE AND ACTION IN POSTMENOPAUSAL WOMEN

Rachael E. Van Pelt1*, Wendolyn S. Gozansky1, Robert S. Schwartz1, and Wendy M. Kohrt1

1 Department of Medicine, Divison of Geriaric Medicine, Center on Aging, University of Colorado Health Sciences Center, Denver, 80262, USA

* To whom correspondence should be addressed. E-mail: rachael.vanpelt{at}uchsc.edu.

To test the hypothesis that estrogens alter insulin action, we evaluated the effects of intravenous (IV) conjugated estrogens (CE) on insulin-stimulated steady-state glucose infusion rate (SSGIR) and suppression of plasma glycerol in postmenopausal women (mean±SD; 56±4 yr; n=12) not using hormone replacement. SSGIR and glycerol were measured during a 2-stage (8 and 40 mU/m2/min) hyperinsulinemic, euglycemic clamp on 2 days with or without a 2.5-mg CE IV bolus. Serum estradiol concentrations were increased ~200% on estrogen (EST) compared with the control (CON) days. Serum insulin was reduced (p<0.01) during stage 2 of the clamp for EST (63.3±12.8 µU/mL) vs CON (78.2±15.8 µU/mL). Mean SSGIR and plasma glycerol did not differ between CON and EST days. Adjusting for differences in insulin concentration between conditions, stage 2 glucose disposals were significantly higher (8.63 vs 7.20 mg/kg/min) and plasma glycerol concentrations were significantly lower (29.4 vs 35.0 µmol/L) for EST vs CON. Our findings suggest acute CE administration increases insulin clearance and action in postmenopausal women.




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