We tested the hypothesis that reductions in total body and abdominal visceral fat with energy restriction would be associated with increases in cardiovagal BRS in overweight/obese older men. To address this, overweight/obese (25BMI35 kg/ms²) young (OB-Y, n=10, age=32.9±2.3 yrs) and older (OB-O, n=6, age=60 2.7 yrs) men underwent 3 months of energy restriction at a level designed to reduce body weight by 5-10%. Cardiovagal BRS (modified Oxford technique), body composition (dual energy x-ray absorptiometry), and abdominal fat distribution (computed tomography) were measured in the overweight/obese men prior to weight loss and following 4 weeks of weight stability at their reduced weight and compared to a group of nonobese young men (NO-Y, n=13, age=21.1±1.0 yrs). Prior to weight loss, cardiovagal BRS was ~35% and ~60% lower (P<0.05) in the OB-Y and OB-O compared with nonobese young men. Body weight (-7.8±1.1 vs. -7.3±0.7 kg), total fat mass (-4.1±1.0 vs. -4.4±0.8 kg), and abdominal visceral fat (-27.6±6.9 vs. -43.5 ±10.1 cm²) were reduced (all P<0.05) after weight loss but the magnitude of reduction did not differ (all P>0.05) between OB-Y and OB-O, respectively. Cardiovagal BRS increased (11.5±1.9 vs. 18.5±2.6 msec/mmHg) and (6.7±1.2 vs. 12.8±4.2 msec/mmHg) following weight loss (both P<0.05) in OB-Y and OB-O, respectively. Following weight loss, cardiovagal BRS in the young and older obese/overweight men was ~105% and ~73% (P>0.05) of NO (17.5±2.2 msec/mmHg). Therefore, the results of this study indicate that weight loss increases the sensitivity of the cardiovagal baroreflex in overweight/obese young and older men.