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Am J Physiol Endocrinol Metab (December 10, 2002). doi:10.1152/ajpendo.00478.2002
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Articles in PresS, published online ahead of print December 10, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00478.2002
Submitted on October 31, 2002
Accepted on December 2, 2002

Thyroid status, but not insulin status, affects expression of avian uncoupling protein mRNA in chicken

Anne Collin1*, Mohammed Taouis1, Johan Buyse2, Ndey B. Ifuta3, Veerle M. Darras4, Pieter Van As2, Ramon D. Malheiros2, Vera M. Moraes5, and Eddy Decuypere2

1 Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Nouzilly, France
2 Laboratory for Physiology of Domestic Animals, Department of Animal Production, K.U. Leuven, Leuven, Belgium
3 Departement de Biologie, ISP-GOMBE, Kinshasa/Gombe, Congo, Democratic Republic
4 Laboratory of Comparative Endocrinology, K.U. Leuven, Leuven, Belgium
5 Laboratory for Physiology of Domestic Animals, Department of Animal Production, K.U. Leuven, Leuven, Belgium; Departamento de Zootecnia, Faculdade de Ciencas Agrarias e Veterinarias - UNESP, Jaboticabal - SP, Brazil

* To whom correspondence should be addressed. E-mail: collin{at}tours.inra.fr.

The aim of this study was to investigate the hormonal regulation of the avian homolog of mammalian uncoupling protein (avUCP) by studying the impact of thyroid hormones and insulin on avUCP mRNA expression in chickens (Gallus gallus). For three weeks, chicks received either a standard diet (Control group), or a standard diet supplemented with triiodothyronine T3 (T3 group) or with the thyroid gland inhibitor methimazole (MMI group). A fourth group received injections of the deiodinase inhibitor iopanoic acid (IOP group). During the fourth week of age, all animals received two daily injections of either human insulin or saline solution. The results indicate a two-fold overexpression of avUCP mRNA expression in gastrocnemius muscle of T3 birds and a clear down-regulation (-74%) in MMI chickens, as compared to control chickens. Insulin injections had no significant effect on avUCP mRNA expression in chickens. This study describes for the first time induction of avUCP mRNA expression by the thermogenic hormone triiodothyronine in chickens and supports a possible involvement of avUCP in avian thermogenesis.




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