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Am J Physiol Endocrinol Metab (December 16, 2003). doi:10.1152/ajpendo.00445.2003
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Submitted on October 2, 2003
Accepted on December 12, 2003

Islet cell engraftment and control of diabetes in rats following transplantation of pig pancreatic anlagen

Sharon A. Rogers1, Feng Chen1, Mike Talcott2, and Marc R. Hammerman3*

1 Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
2 Renal Division, Department of Comparative Medicine, Washington University School of Medicine, St. Louis, Missouri, USA
3 Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA; Renal Division, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA

* To whom correspondence should be addressed. E-mail: mhammerm{at}im.wustl.edu.

The insufficient supply of tissue, loss post-transplantation and limited potential for expansion of beta cells restricts the use of islet allotransplantation for diabetes. A way to overcome the supply and expansion problems is to xenotransplant embryonic tissue. We have shown that whole rat pancreatic anlagen isotransplanted into the omentum of rats, or xenotransplanted into co-stimulatory blocked mice undergo growth and differentiate into islets surrounded by stoma without exocrine tissue. Isotransplants normalize glucose tolerance in diabetic hosts. Here we show that embryonic day 29 porcine pancreas transplanted into the omentum of adult diabetic rats undergoes endocrine tissue differentiation over 20 weeks, and normalizes body weights and glucose tolerance. Unlike rat to rodent transplants, individual alpha and beta cells engraft without a stromal component, and no immunosuppression is required for pig to rat transplants. Herein is described a novel means to effect the xenotransplantation of individual islet cells across a highly disparate barrier.




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