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Articles in PresS, published online ahead of print December 10, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00411.2002
Submitted on September 17, 2002
Accepted on December 3, 2002
1 Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA
2 Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
* To whom correspondence should be addressed. E-mail: mittendb{at}medicine.wustl.edu.
We have previously shown that sex and obesity independently affect basal VLDL-triglyceride (TG) kinetics. In the present study, we investigated the effect of hyperglycemia and hyperinsulinemia on VLDL-TG kinetics in lean and obese men and women (n=6 in each group). VLDL-TG kinetics were measured during basal, postabsorptive conditions and during glucose infusion (5.5 mg.kg FFM-1 .min-1) by using [2H5]glycerol bolus injection in conjunction with compartmental modeling analysis. Basal VLDL-TG secretion into plasma was greater in obese than lean men (7.8 ± 0.6 and 2.9 ± 0.4 µmol.L plasma-1 .min-1; p<0.001) but was not different in lean and obese women (5.0 ± 1.1 and 5.9 ± 1.1 µmol.L plasma-1 .min-1). Glucose infusion decreased VLDL-TG secretion rate by ~50% in lean and obese men and in lean women (to 1.5 ± 0.4, 4.0 ± 0.6, and 2.2 ± 0.4 µmol.L plasma-1 .min-1, respectively; all p<0.05), but had no effect on VLDL-TG secretion rate in obese women (4.9 ± 1.0 µmol.L plasma-1 .min-1). These results demonstrate that both sex and adiposity affect the regulation of VLDL-TG metabolism. Glucose and insulin decrease VLDL-TG secretion in both lean men and lean women; obesity is associated with resistance to the glucose-insulin mediated suppression of VLDL-TG secretion in women, but not in men.
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