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1 Stockholm University, The Wenner-Gren Institute, Stockholm, Sweden
* To whom correspondence should be addressed. E-mail: jan{at}metabol.su.se.
Participation of brown adipose tissue (through the action of the uncoupling protein UCP1) in adaptive adrenergic nonshivering thermogenesis is recognized, but the existence of a response to adrenergic stimulation in UCP1-ablated mice implies that a mechanism for an alternative adaptive adrenergic thermogenesis may exist. We have here used UCP1-ablated mice to examine the existence of an alternative adaptive adrenergic nonshivering thermogenesis, examined as the oxygen consumption response to systemically injected norepinephrine into anaesthetized or conscious mice, acclimated to different temperatures. While confirming that UCP1-dependent adrenergic nonshivering thermogenesis is adaptive, we demonstrate that the adrenergic UCP1-independent thermogenesis is not recruitable by cold acclimation. Thus, at least in the mouse, no other proteins or enzymatic pathways exist that can participate in or with time take over the UCP1-mediation of adaptive adrenergic nonshivering thermogenesis, even in the total absence of UCP1. UCP1 is thus the only protein capable of mediating cold-acclimation-recruited adaptive adrenergic nonshivering thermogenesis.
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