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Am J Physiol Endocrinol Metab (December 10, 2002). doi:10.1152/ajpendo.00379.2002
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Articles in PresS, published online ahead of print December 10, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00379.2002
Submitted on August 26, 2002
Accepted on November 7, 2002

Effect of Weight Loss on VLDL-Triglyceride and Apolipoprotein B-100 Kinetics in Women with Abdominal Obesity

Bettina Mittendorfer1, Bruce W. Patterson1, and Samuel Klein1*

1 Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA

* To whom correspondence should be addressed. E-mail: sklein{at}im.wustl.edu.

The effects of obesity and weight loss on lipoprotein kinetics were evaluated in 6 lean women (BMI: 21±1 kg/m2) and 7 women with abdominal obesity (BMI: 36±1 kg/m2). Stable isotope tracer techniques, in conjunction with compartmental modeling, were used to determine VLDL-triglyceride (TG) and apolipoprotein B-100 (apoB-100) secretion rates in lean women and in obese women before and after 10% weight loss. VLDL-TG and VLDL-apoB-100 secretion rates were similar in lean and obese women. Weight loss decreased the rate of VLDL-TG secretion by ~40% (from 0.41±0.05 to 0.23±0.03 µmol.kg FFM-1.min-1; p<0.05). The relative decline in VLDL-TG produced from non-systemic fatty acids, derived from intraperitoneal and intrahepatic TG, was greater (61±7%) than the decline in VLDL-TG produced from systemic fatty acids, predominately derived from subcutaneous TG, (25±8 %; p<0.05). Weight loss did not affect VLDL-apoB-100 secretion rate. We conclude that weight-loss decreases the rate of VLDL-TG secretion in women with abdominal obesity, primarily by decreasing the availability of non-systemic fatty acids. There is a dissociation in the effect of weight loss on VLDL-TG and apoB-100 metabolic pathways, which may affect VLDL particle size.




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