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Am J Physiol Endocrinol Metab (November 13, 2001). doi:10.1152/ajpendo.00373.2001
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Articles in PresS, published online ahead of print November 13, 2001
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00373.2001
Submitted on August 16, 2001
Accepted on November 7, 2001

Vascular Recruitment in Skeletal Muscle During Exercise and Hyperinsulinemia Assessed by Contrast Ultrasound

Dana Dawson1, Michelle A Vincent2, Eugene J Barrett2, Sanjiv Kaul1, Andrew Clark2, Howard Leong-Poi1, and Jonathan R Lindner1*

1 Cardiovascular Division, University of Virginia, Charlottesville, VA, USA
2 Endocrinology Division, University of Virginia, Charlottesville, VA, USA

* To whom correspondence should be addressed. E-mail: jlindner{at}virginia.edu.

The purpose of this study was to non-invasively quantify the effects of insulin on capillary blood volume (capBV) and RBC velocity (VRBC) in skeletal muscle in vivo using contrast-enhanced ultrasound. We performed contrast ultrasound of the rat hindlimb adductor muscles during at baseline, after 2 h infusions of either insulin (3 or 40 mU*kg-1*min-1) or saline, and during contractile exercise. VRBC and capBV were calculated from the relation between pulsing interval and video intensity. Femoral artery blood flow, measured by a flow probe, increased with both contractile exercise and insulin. Contractile exercise increased capBV by >2-fold and VRBC by 5-fold. Insulin also increased capBV by >2-fold in a dose-dependent fashion but did not significantly alter VRBC. Saline infusion did not significantly alter capBV, VRBC, or femoral artery blood flow. We conclude that physiologic changes in skeletal muscle capillary perfusion can be assessed in vivo using contrast-enhanced ultrasound. Exercise increases both VRBC and capBV, whereas physiologic hyperinsulinemia selectively increases only capBV, which may enhance skeletal muscle glucose uptake.




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